Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma
Clinical imaging methods, such as computed tomography (CT), are used for routine tumor response monitoring. Imaging can also reveal intratumoral, intermetastatic, and interpatient heterogeneity, which can be quantified using radiomics. Circulating tumor DNA (ctDNA) in the plasma is a sensitive and s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/12/3493 |
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| author | Andrew B Gill Leonardo Rundo Jonathan C. M. Wan Doreen Lau Jeries P. Zawaideh Ramona Woitek Fulvio Zaccagna Lucian Beer Davina Gale Evis Sala Dominique-Laurent Couturier Pippa G. Corrie Nitzan Rosenfeld Ferdia A. Gallagher |
| author_facet | Andrew B Gill Leonardo Rundo Jonathan C. M. Wan Doreen Lau Jeries P. Zawaideh Ramona Woitek Fulvio Zaccagna Lucian Beer Davina Gale Evis Sala Dominique-Laurent Couturier Pippa G. Corrie Nitzan Rosenfeld Ferdia A. Gallagher |
| author_sort | Andrew B Gill |
| collection | DOAJ |
| description | Clinical imaging methods, such as computed tomography (CT), are used for routine tumor response monitoring. Imaging can also reveal intratumoral, intermetastatic, and interpatient heterogeneity, which can be quantified using radiomics. Circulating tumor DNA (ctDNA) in the plasma is a sensitive and specific biomarker for response monitoring. Here we evaluated the interrelationship between circulating tumor DNA mutant allele fraction (ctDNA<i>maf</i>), obtained by targeted amplicon sequencing and shallow whole genome sequencing, and radiomic measurements of CT heterogeneity in patients with stage IV melanoma. ctDNA<i>maf</i> and radiomic observations were obtained from 15 patients with a total of 70 CT examinations acquired as part of a prospective trial. 26 of 39 radiomic features showed a significant relationship with log(ctDNA<i>maf</i>). Principal component analysis was used to define a radiomics signature that predicted ctDNA<i>maf</i> independent of lesion volume. This radiomics signature and serum lactate dehydrogenase were independent predictors of ctDNA<i>maf</i>. Together, these results suggest that radiomic features and ctDNA<i>maf</i> may serve as complementary clinical tools for treatment monitoring. |
| first_indexed | 2024-03-10T14:36:58Z |
| format | Article |
| id | doaj.art-7635b90d886e451d8953af19feef04b9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:36:58Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7635b90d886e451d8953af19feef04b92023-11-20T22:06:18ZengMDPI AGCancers2072-66942020-11-011212349310.3390/cancers12123493Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic MelanomaAndrew B Gill0Leonardo Rundo1Jonathan C. M. Wan2Doreen Lau3Jeries P. Zawaideh4Ramona Woitek5Fulvio Zaccagna6Lucian Beer7Davina Gale8Evis Sala9Dominique-Laurent Couturier10Pippa G. Corrie11Nitzan Rosenfeld12Ferdia A. Gallagher13Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKCancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UKDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UKCancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UKDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UKClinical imaging methods, such as computed tomography (CT), are used for routine tumor response monitoring. Imaging can also reveal intratumoral, intermetastatic, and interpatient heterogeneity, which can be quantified using radiomics. Circulating tumor DNA (ctDNA) in the plasma is a sensitive and specific biomarker for response monitoring. Here we evaluated the interrelationship between circulating tumor DNA mutant allele fraction (ctDNA<i>maf</i>), obtained by targeted amplicon sequencing and shallow whole genome sequencing, and radiomic measurements of CT heterogeneity in patients with stage IV melanoma. ctDNA<i>maf</i> and radiomic observations were obtained from 15 patients with a total of 70 CT examinations acquired as part of a prospective trial. 26 of 39 radiomic features showed a significant relationship with log(ctDNA<i>maf</i>). Principal component analysis was used to define a radiomics signature that predicted ctDNA<i>maf</i> independent of lesion volume. This radiomics signature and serum lactate dehydrogenase were independent predictors of ctDNA<i>maf</i>. Together, these results suggest that radiomic features and ctDNA<i>maf</i> may serve as complementary clinical tools for treatment monitoring.https://www.mdpi.com/2072-6694/12/12/3493liquid biopsycirculating tumor DNAtumor heterogeneitytumor imagingradiomics |
| spellingShingle | Andrew B Gill Leonardo Rundo Jonathan C. M. Wan Doreen Lau Jeries P. Zawaideh Ramona Woitek Fulvio Zaccagna Lucian Beer Davina Gale Evis Sala Dominique-Laurent Couturier Pippa G. Corrie Nitzan Rosenfeld Ferdia A. Gallagher Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma Cancers liquid biopsy circulating tumor DNA tumor heterogeneity tumor imaging radiomics |
| title | Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma |
| title_full | Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma |
| title_fullStr | Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma |
| title_full_unstemmed | Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma |
| title_short | Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma |
| title_sort | correlating radiomic features of heterogeneity on ct with circulating tumor dna in metastatic melanoma |
| topic | liquid biopsy circulating tumor DNA tumor heterogeneity tumor imaging radiomics |
| url | https://www.mdpi.com/2072-6694/12/12/3493 |
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