Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis

Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis

The activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) are central events in hepatic fibrogenesis. These processes are driven by autocrine- and paracrine-acting soluble factors (i.e. cytokines and chemokines). Proof-of-concep...

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Bibliographic Details
Main Authors: Hans-Theo eSchon, Matthias eBartneck, Erawan eBorkham-Kamphorst, Jacob eNattermann, Twan eLammers, Frank eTacke, Ralf eWeiskirchen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Pharmacology
Subjects:
Gene Therapy
biomedicine
differential expression
Drug Targeting
Liver disease
antifibrotic
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00033/full

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