Soyasaponin Ab protects against oxidative stress in HepG2 cells via Nrf2/HO-1/NQO1 signaling pathways

Soyasaponin Ab protects against oxidative stress in HepG2 cells via Nrf2/HO-1/NQO1 signaling pathways

Soyasaponin Ab (SA) is a typical oleanane triterpene saponin isolated from soybean and represents effects of antioxidation and anti-inflammation. In this study, we found the expressions of some phase II detoxifying enzymes were stimulated by SA via the signaling pathway of nuclear factor erythroid 2...

Full description

Bibliographic Details
Main Authors:	Xiuying Liu, Keke Chen, Lijie Zhu, He Liu, Tao Ma, Qingying Xu, Tianyu Xie
Format:	Article
Language:	English
Published:	Elsevier 2018-06-01
Series:	Journal of Functional Foods
Subjects:	Nrf2 Soyasaponin Antioxidant activity Oxidative stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464618301233

Similar Items

Stability and rheological properties of water-in-oil (W/O) emulsions prepared with a soyasaponin-PGPR system
by: Yueying Pan, et al.
Published: (2021-12-01)

Selective reduction of fat accumulation by soyasaponins A and B in high fat fed C57BL/6J mice
by: R.S. Govardhan Singh, et al.
Published: (2016-12-01)

Secretion dynamics of soyasaponins in soybean roots and effects to modify the bacterial composition
by: Teruhisa Fujimatsu, et al.
Published: (2020-09-01)

Soyasaponin Ab alleviates postmenopausal obesity through browning of white adipose tissue
by: Han-Jun Kim, et al.
Published: (2019-06-01)

In vitro study of sodium butyrate on soyasaponin challenged intestinal epithelial cells of turbot (Scophthalmus maximus L.) refer to inflammation, apoptosis and antioxidant enzymes
by: Guijuan Yu, et al.
Published: (2021-12-01)

Enhancement in humoral response against inactivated Newcastle disease vaccine in broiler chickens administered orally with plant-derived soyasaponin
by: Ghania Naveed, et al.
Published: (2020-04-01)

Effect of a diet containing a mixture of soybean isoflavones and soyasaponins on contact hypersensitivity and gut microbiota in mice
by: Takao Nagano, et al.
Published: (2021-09-01)

Soyasaponin I alleviates hypertensive intracerebral hemorrhage by inhibiting the renin–angiotensin–aldosterone system
by: Wei Li, et al.
Published: (2023-12-01)

Anti-Colon Cancer Activity of Dietary Phytochemical Soyasaponin I and the Induction of Metabolic Shifts in HCT116
by: Xuewei Xia, et al.
Published: (2022-07-01)

Soyasaponin A1 inhibits the lipid raft recruitment and dimerization of TLR4, MyD88, and TRIF by maintaining cholesterol homeostasis in palmitic acid-stimulated inflammatory Raw264.7 macrophage cell line
by: Xiangfu Gu, et al.
Published: (2021-12-01)

Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway
by: Rui Hu, et al.
Published: (2024-12-01)

Combined exposure to manganese and iron decreases oxidative stress-induced nerve damage by increasing Nrf2/HO-1/NQO1 expression
by: Yuan-yuan Fang, et al.
Published: (2024-01-01)

Jian-Pi-Bu-Xue-Formula Alleviates Cyclophosphamide-Induced Myelosuppression via Up-Regulating NRF2/HO1/NQO1 Signaling
by: Qiuju Huang, et al.
Published: (2020-08-01)

Protective effects of neoagarotetraose against oxidative stress via Nrf2/HO-1 signaling pathway in hydrogen peroxide-induced HepG2 cells
by: Yayan Huang, et al.
Published: (2024-03-01)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
by: Junbin Chen, et al.
Published: (2020-06-01)

Differential Yet Integral Contributions of Nrf1 and Nrf2 in the Human HepG2 Cells on Antioxidant Cytoprotective Response against <i>Tert</i>-Butylhydroquinone as a Pro-Oxidative Stressor
by: Reziyamu Wufuer, et al.
Published: (2021-10-01)

Eckol Enhances Heme Oxygenase-1 Expression through Activation of Nrf2/JNK Pathway in HepG2 Cells
by: Young-Jin Jun, et al.
Published: (2014-09-01)

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson’s disease by promoting Nrf2/NQO-1 pathway
by: Huang Lijuan, et al.
Published: (2022-09-01)

Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells
by: Jihua Chen, et al.
Published: (2019-07-01)

Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling
by: Mengyuan Wang, et al.
Published: (2023-02-01)

Anti-tumor effects of Soyasaponin IV as a natural product in Ehrlich ascites carcinoma bearing mice: modulation of monocyte vascular endothelial growth factor (VEFG) and nuclear factor kappa B (NF-κB) pathways
by: Samar A. Antar, et al.
Published: (2024-12-01)

Transport Stress Induced Cardiac NO-NOS Disorder Is Mitigated by Activating Nrf2/HO-1/NQO1 Antioxidant Defense Response in Newly Hatched Chicks
by: Hao-Liang Xu, et al.
Published: (2022-06-01)

DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells
by: Huan Liu, et al.
Published: (2021-09-01)

The Association Between Oxidative Stress Alleviation via Sulforaphane-Induced Nrf2-HO-1/NQO-1 Signaling Pathway Activation and Chronic Renal Allograft Dysfunction Improvement
by: Daoyuan Lv, et al.
Published: (2018-02-01)

Corrigendum: Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling
by: Mengyuan Wang, et al.
Published: (2023-05-01)

Effects of Phthalate Esters (PAEs) on Cell Viability and Nrf2 of HepG2 and 3D-QSAR Studies
by: Huan Liu, et al.
Published: (2021-06-01)

Composition variability in soy-derived dietary supplements designated for menopausal symptom prevention
by: Hubert Jane, et al.
Published: (2006-09-01)

Wheat bran feruloyl oligosaccharides ameliorate AAPH-induced oxidative stress in HepG2 cells via Nrf2 signalling
by: Huijuan Zhang, et al.
Published: (2016-08-01)

Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway
by: Wu S, et al.
Published: (2016-10-01)

Protective effects of bitter acids from Humulus lupulus L. against senile osteoporosis via activating Nrf2/HO-1/NQO1 pathway in D-galactose induced aging mice
by: Shengyan Xu, et al.
Published: (2022-07-01)

Syringic acid ameliorates testicular oxidative stress via the conservation of endogenous antioxidant markers and inhibition of the activated Nrf2-Keap1-NQO1-HO1 signaling in methyl cellosolve-administered rats
by: Oluwatobi T. Somade, et al.
Published: (2023-03-01)

Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
by: Atena Mansouri, et al.
Published: (2022-02-01)

Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells
by: G. R. Sharath Babu, et al.
Published: (2017-11-01)

2-Fluorofucose Attenuates Hydrogen Peroxide-Induced Oxidative Stress in HepG2 Cells via Nrf2/keap1 and NF-κB Signaling Pathways
by: Mengjue Tu, et al.
Published: (2022-03-01)

Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model
by: Nobunao Wakabayashi, et al.
Published: (2023-08-01)

Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells
by: Yanan Zhao, et al.
Published: (2023-11-01)

Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways
by: Zhang J, et al.
Published: (2021-02-01)

Electrophilic thymol isobutyrate from Inula nervosa Wall. (Xiaoheiyao) ameliorates steatosis in HepG2 cells via Nrf2 activation
by: Xiang-Rong Cheng, et al.
Published: (2022-01-01)

Chemically Defined <i>Lactobacillus plantarum</i> Cell-Free Metabolites Demonstrate Cytoprotection in HepG2 Cells through Nrf2-Dependent Mechanism
by: Raja Rezgui, et al.
Published: (2023-04-01)

Oxidative Stress Modulation by Cameroonian Spice Extracts in HepG2 Cells: Involvement of Nrf2 and Improvement of Glucose Uptake
by: Achille Parfait Atchan Nwakiban, et al.
Published: (2020-05-01)