Small Molecules of Marine Origin as Potential Anti-Glioma Agents
Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WH...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/9/2707 |
| _version_ | 1797535222599778304 |
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| author | Ana Alves Paulo Costa Madalena Pinto Domingos Ferreira Marta Correia-da-Silva |
| author_facet | Ana Alves Paulo Costa Madalena Pinto Domingos Ferreira Marta Correia-da-Silva |
| author_sort | Ana Alves |
| collection | DOAJ |
| description | Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment. |
| first_indexed | 2024-03-10T11:41:28Z |
| format | Article |
| id | doaj.art-763c05146dc64ff0a52e35a03871c677 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:41:28Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-763c05146dc64ff0a52e35a03871c6772023-11-21T18:25:11ZengMDPI AGMolecules1420-30492021-05-01269270710.3390/molecules26092707Small Molecules of Marine Origin as Potential Anti-Glioma AgentsAna Alves0Paulo Costa1Madalena Pinto2Domingos Ferreira3Marta Correia-da-Silva4UCIBIO, REQUIMTE, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, PortugalUCIBIO, REQUIMTE, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, PortugalLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, PortugalUCIBIO, REQUIMTE, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, PortugalLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, PortugalMarine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment.https://www.mdpi.com/1420-3049/26/9/2707gliomamarine compounddrug discovery |
| spellingShingle | Ana Alves Paulo Costa Madalena Pinto Domingos Ferreira Marta Correia-da-Silva Small Molecules of Marine Origin as Potential Anti-Glioma Agents Molecules glioma marine compound drug discovery |
| title | Small Molecules of Marine Origin as Potential Anti-Glioma Agents |
| title_full | Small Molecules of Marine Origin as Potential Anti-Glioma Agents |
| title_fullStr | Small Molecules of Marine Origin as Potential Anti-Glioma Agents |
| title_full_unstemmed | Small Molecules of Marine Origin as Potential Anti-Glioma Agents |
| title_short | Small Molecules of Marine Origin as Potential Anti-Glioma Agents |
| title_sort | small molecules of marine origin as potential anti glioma agents |
| topic | glioma marine compound drug discovery |
| url | https://www.mdpi.com/1420-3049/26/9/2707 |
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