HHV8-positive multicentric Castleman’s disease and thrombotic thrombocytopenic purpura among HIV-positive patients

HHV8-positive multicentric Castleman’s disease and thrombotic thrombocytopenic purpura among HIV-positive patients

Castleman’s disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In this study, we present a case of a 53-year-old p...

Full description

Bibliographic Details
Main Authors: Roxane Pasquer, Yannick Dieudonné, Pauline Decours, Olivier Hinschberger, Alina Nicolae, Martin Martinot
Format: Article
Language:English
Published: SMC MEDIA SRL 2024-02-01
Series:European Journal of Case Reports in Internal Medicine
Subjects:
castleman’s disease
thrombotic thrombocytopenic purpura
hhv8
hiv
auto-immune hypoglycemia
Online Access:https://www.ejcrim.com/index.php/EJCRIM/article/view/4361
Description
Summary:Castleman’s disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In this study, we present a case of a 53-year-old patient with controlled HIV infection who presented with fever, lymphadenopathy, severe anaemia, and thrombocytopenia. After a series of tests, the diagnosis was concurrent human herpesvirus 8 (HHV8)-related multicentric CD (MCD) and TTP. Only four male patients were previously reported having this association, with HHV8 present in four and HIV in three patients, suggesting that coinfection with HHV8 and HIV is a pivotal factor in MCD with TTP occurrence.
ISSN:2284-2594

Similar Items