Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a

Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a

In acute myeloid leukemia (AML), the restoration of p53 activity through MDM2 inhibition proved efficacy in combinatorial therapies. WIP1, encoded from <i>PPM1D</i>, is a negative regulator of p53. We evaluated <i>PPM1D</i> expression and explored the therapeutic efficacy of...

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Bibliographic Details
Main Authors:	Maria Chiara Fontana, Jacopo Nanni, Andrea Ghelli Luserna di Rorà, Elisabetta Petracci, Antonella Padella, Martina Ghetti, Anna Ferrari, Giovanni Marconi, Simona Soverini, Ilaria Iacobucci, Cristina Papayannidis, Antonio Curti, Ernesta Audisio, Maria Benedetta Giannini, Michela Rondoni, Francesco Lanza, Michele Cavo, Giovanni Martinelli, Giorgia Simonetti
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Biomedicines
Subjects:	AML novel therapeutic targets <i>WIP1</i> <i>MDM2</i>
Online Access:	https://www.mdpi.com/2227-9059/9/4/388

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