Concordance between culture, Molecular Culture and Illumina 16S rRNA gene amplicon sequencing of bone and ulcer bed biopsies in people with diabetic foot osteomyelitis

Concordance between culture, Molecular Culture and Illumina 16S rRNA gene amplicon sequencing of bone and ulcer bed biopsies in people with diabetic foot osteomyelitis

Abstract Background In clinical practice the diagnosis of diabetic foot osteomyelitis (DFO) relies on cultures of bone or ulcer bed (UB) biopsies, of which bone biopsy is reference standard. The slow growth or fastidious nature of some bacteria, hamper expeditious detection and identification. Rapid...

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Bibliographic Details
Main Authors: Meryl Cinzía Tila Tamara Gramberg, Carmen Knippers, Rimke Sabine Lagrand, Jarne Marijn van Hattem, Marcus Christofoor de Goffau, Andries Edward Budding Budding, Mark Davids, Sebastien Matamoros, Max Nieuwdorp, Vincent de Groot, Martin den Heijer, Louise Willy Elizabeth Sabelis, Edgar Josephus Gerardus Peters
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Infectious Diseases
Subjects:
Diabetic foot osteomyelitis
Bone and ulcer bed biopsy
Culture
Molecular culture
16S rRNA gene amplicon sequencing
Online Access:https://doi.org/10.1186/s12879-023-08472-w

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