The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases
Liver disease is a global health burden with high morbidity and mortality worldwide. Liver injuries can develop into severe end-stage diseases, such as cirrhosis or hepatocellular carcinoma, without valid treatment. Therefore, identifying novel drugs may promote liver disease treatment. Phytochemica...
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MDPI AG
2022-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/11/2303 |
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| author | Yijing Ren Siyue Li Zixuan Song Qiuping Luo Yingying Zhang Hao Wang |
| author_facet | Yijing Ren Siyue Li Zixuan Song Qiuping Luo Yingying Zhang Hao Wang |
| author_sort | Yijing Ren |
| collection | DOAJ |
| description | Liver disease is a global health burden with high morbidity and mortality worldwide. Liver injuries can develop into severe end-stage diseases, such as cirrhosis or hepatocellular carcinoma, without valid treatment. Therefore, identifying novel drugs may promote liver disease treatment. Phytochemicals, including polysaccharides, flavonoids, alkaloids, and terpenes, are abundant in foods and medicinal plants and have various bioactivities, such as antioxidation, immunoregulation, and tumor killing. Recent studies have shown that many natural polysaccharides play protective roles in liver disease models in vitro and in vivo, such as fatty liver disease, alcoholic liver disease, drug-induced liver injury, and liver cancer. The mechanisms of liver disease are complex. Notably, ferroptosis, a new type of cell death driven by iron and lipid peroxidation, is considered to be the key mechanism in many hepatic pathologies. Therefore, polysaccharides and other types of phytochemicals with activities in ferroptosis regulation provide novel therapeutic strategies for ferroptosis-related liver diseases. This review summarizes our current understanding of the mechanisms of ferroptosis and liver injury and compelling preclinical evidence of natural bioactive polysaccharides and phytochemicals in treating liver disease. |
| first_indexed | 2024-03-10T00:59:43Z |
| format | Article |
| id | doaj.art-7642b95722064778859f40afa5a4ddb1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:59:43Z |
| publishDate | 2022-05-01 |
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| spelling | doaj.art-7642b95722064778859f40afa5a4ddb12023-11-23T14:36:53ZengMDPI AGNutrients2072-66432022-05-011411230310.3390/nu14112303The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver DiseasesYijing Ren0Siyue Li1Zixuan Song2Qiuping Luo3Yingying Zhang4Hao Wang5Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaLiver disease is a global health burden with high morbidity and mortality worldwide. Liver injuries can develop into severe end-stage diseases, such as cirrhosis or hepatocellular carcinoma, without valid treatment. Therefore, identifying novel drugs may promote liver disease treatment. Phytochemicals, including polysaccharides, flavonoids, alkaloids, and terpenes, are abundant in foods and medicinal plants and have various bioactivities, such as antioxidation, immunoregulation, and tumor killing. Recent studies have shown that many natural polysaccharides play protective roles in liver disease models in vitro and in vivo, such as fatty liver disease, alcoholic liver disease, drug-induced liver injury, and liver cancer. The mechanisms of liver disease are complex. Notably, ferroptosis, a new type of cell death driven by iron and lipid peroxidation, is considered to be the key mechanism in many hepatic pathologies. Therefore, polysaccharides and other types of phytochemicals with activities in ferroptosis regulation provide novel therapeutic strategies for ferroptosis-related liver diseases. This review summarizes our current understanding of the mechanisms of ferroptosis and liver injury and compelling preclinical evidence of natural bioactive polysaccharides and phytochemicals in treating liver disease.https://www.mdpi.com/2072-6643/14/11/2303polysaccharidephytochemicalferroptosisliver injury |
| spellingShingle | Yijing Ren Siyue Li Zixuan Song Qiuping Luo Yingying Zhang Hao Wang The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases Nutrients polysaccharide phytochemical ferroptosis liver injury |
| title | The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases |
| title_full | The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases |
| title_fullStr | The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases |
| title_full_unstemmed | The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases |
| title_short | The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases |
| title_sort | regulatory roles of polysaccharides and ferroptosis related phytochemicals in liver diseases |
| topic | polysaccharide phytochemical ferroptosis liver injury |
| url | https://www.mdpi.com/2072-6643/14/11/2303 |
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