The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy
OPMDs (oral potentially malignant disorders) are a group of disorders affecting the oral mucosa that are characterized by aberrant cell proliferation and a higher risk of malignant transformation. Vitamin D (VitD) and its receptor (VDR) have been extensively studied for their potential contributions...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/20/15058 |
| _version_ | 1797573703351926784 |
|---|---|
| author | Aya Khamis Lara Salzer Eik Schiegnitz Roland H. Stauber Désirée Gül |
| author_facet | Aya Khamis Lara Salzer Eik Schiegnitz Roland H. Stauber Désirée Gül |
| author_sort | Aya Khamis |
| collection | DOAJ |
| description | OPMDs (oral potentially malignant disorders) are a group of disorders affecting the oral mucosa that are characterized by aberrant cell proliferation and a higher risk of malignant transformation. Vitamin D (VitD) and its receptor (VDR) have been extensively studied for their potential contributions to the prevention and therapeutic management of various diseases and neoplastic conditions, including oral cancer. Observational studies suggest correlations between VitD deficiency and higher cancer risk, worse prognosis, and increased mortality rates. Interestingly, emerging data also suggest a link between VitD insufficiency and the onset or progression of OPMDs. Understanding the role of the VitD–VDR axis not only in established oral tumors but also in OPMDs might thus enable early detection and prevention of malignant transformation. With this article, we want to provide an overview of current knowledge about OPMDs and VitD and investigate their potential association and ramifications for clinical management of OPMDs. |
| first_indexed | 2024-03-10T21:12:47Z |
| format | Article |
| id | doaj.art-76435b347f6445bdbdaabc9776f56abf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:12:47Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-76435b347f6445bdbdaabc9776f56abf2023-11-19T16:41:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124201505810.3390/ijms242015058The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and MalignancyAya Khamis0Lara Salzer1Eik Schiegnitz2Roland H. Stauber3Désirée Gül4Department of Otorhinolaryngology Head and Neck Surgery, Molecular and Cellular Oncology, University Medical Center, 55131 Mainz, GermanyDepartment of Otorhinolaryngology Head and Neck Surgery, Molecular and Cellular Oncology, University Medical Center, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg—University Mainz, 55131 Mainz, GermanyDepartment of Otorhinolaryngology Head and Neck Surgery, Molecular and Cellular Oncology, University Medical Center, 55131 Mainz, GermanyDepartment of Otorhinolaryngology Head and Neck Surgery, Molecular and Cellular Oncology, University Medical Center, 55131 Mainz, GermanyOPMDs (oral potentially malignant disorders) are a group of disorders affecting the oral mucosa that are characterized by aberrant cell proliferation and a higher risk of malignant transformation. Vitamin D (VitD) and its receptor (VDR) have been extensively studied for their potential contributions to the prevention and therapeutic management of various diseases and neoplastic conditions, including oral cancer. Observational studies suggest correlations between VitD deficiency and higher cancer risk, worse prognosis, and increased mortality rates. Interestingly, emerging data also suggest a link between VitD insufficiency and the onset or progression of OPMDs. Understanding the role of the VitD–VDR axis not only in established oral tumors but also in OPMDs might thus enable early detection and prevention of malignant transformation. With this article, we want to provide an overview of current knowledge about OPMDs and VitD and investigate their potential association and ramifications for clinical management of OPMDs.https://www.mdpi.com/1422-0067/24/20/15058VitDVitD receptorOPMDSCCpremalignancywhite lesions |
| spellingShingle | Aya Khamis Lara Salzer Eik Schiegnitz Roland H. Stauber Désirée Gül The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy International Journal of Molecular Sciences VitD VitD receptor OPMD SCC premalignancy white lesions |
| title | The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy |
| title_full | The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy |
| title_fullStr | The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy |
| title_full_unstemmed | The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy |
| title_short | The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy |
| title_sort | magic triangle in oral potentially malignant disorders vitamin d vitamin d receptor and malignancy |
| topic | VitD VitD receptor OPMD SCC premalignancy white lesions |
| url | https://www.mdpi.com/1422-0067/24/20/15058 |
| work_keys_str_mv | AT ayakhamis themagictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT larasalzer themagictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT eikschiegnitz themagictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT rolandhstauber themagictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT desireegul themagictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT ayakhamis magictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT larasalzer magictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT eikschiegnitz magictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT rolandhstauber magictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy AT desireegul magictriangleinoralpotentiallymalignantdisordersvitamindvitamindreceptorandmalignancy |