P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice

P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice

Abstract Background Central sensitization is an important pathophysiological mechanism of chronic migraine (CM). According to our previous studies, microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute to the central sensitization. The P2X7 receptor (P...

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Bibliographic Details
Main Authors: Li Jiang, Yixin Zhang, Feng Jing, Ting Long, Guangcheng Qin, Dunke Zhang, Lixue Chen, Jiying Zhou
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
P2X7R
Autophagy
Microglia
Inflammation
Central sensitization
Chronic migraine
Online Access:https://doi.org/10.1186/s12974-020-02056-0

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