Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs

Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs

Survivin as a member of the inhibitor of apoptosis proteins (IAPs) family is undetectable in normal cells, but highly expressed in cancer cells and cancer stem cells (CSCs) which makes it an attractive target in cancer therapy. Survivin dominant negative mutants have been reported as competitive inh...

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Bibliographic Details
Main Authors: Wei Guo, Xingyuan Ma, Yunhui Fu, Chang Liu, Qiuli Liu, Fabiao Hu, Hui Miao, Tong Zhang, Yuping Liu, Myong Hun Han, Fang You, Yi Yang, Wenyun Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
survivin mutant (TmSm34/84)
A549 cells and CSCs
discovering and characterizing
stronger pro-apoptotic activity
sensitizing chemotherapeutic drugs
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.635233/full

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