Genesis of fatty liver and hyperlipemia in the fetal guinea pig.
10 to 20% of [1-14C] palmitate injected into pregnant guinea pigs was recovered in lipids of their fetuses. From these data and the rate of transport of palmitate in maternal blood, it appears that placental transport of free fatty acids can account for the accumulation of lipids in late gestational...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1975-11-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520344965 |
| _version_ | 1818743186588172288 |
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| author | T Bohmer R J Havel |
| author_facet | T Bohmer R J Havel |
| author_sort | T Bohmer |
| collection | DOAJ |
| description | 10 to 20% of [1-14C] palmitate injected into pregnant guinea pigs was recovered in lipids of their fetuses. From these data and the rate of transport of palmitate in maternal blood, it appears that placental transport of free fatty acids can account for the accumulation of lipids in late gestational fetuses. About 80% of the labeled palmitate in the fetus appeared initially in lipids of the liver. 14C appeared in plasma triglyceride fatty acids after a few minutes and subsequently accumulated in lipids of white and brown adipose tissue, suggesting that much of the palmitate deposited in adipose tissue were derived from hepatogenous triglyceride fatty acids. By contrast, 14C was usually maximal in heart and carcass lipids before it appeared in plasma triglyceride fatty acids. Lipoprotein lipase activity in fetal adipose tissue was low, and activity of cofactor protein of lipoprotein lipase in fetal blood plasma was much lower than that observed in other mammalian species. On the basis of these and earlier observations, it is concluded that the accumulation of triglycerides in liver and blood plasma of fetal guinea pigs during late gestation is at least partly the result of the large uptake of maternally derived free fatty acids by the fetal liver accompanied by rapid synthesis and secretion of triglyceride-rich very low density lipoproteins into the blood. However, limited uptake of triglyceride fatty acids in adipose tissue may contribute to the fatty liver and hyperlipemia. |
| first_indexed | 2024-12-18T02:24:25Z |
| format | Article |
| id | doaj.art-764b431dfc434ce79838287bad990d20 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-18T02:24:25Z |
| publishDate | 1975-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-764b431dfc434ce79838287bad990d202022-12-21T21:24:06ZengElsevierJournal of Lipid Research0022-22751975-11-01166454460Genesis of fatty liver and hyperlipemia in the fetal guinea pig.T BohmerR J Havel10 to 20% of [1-14C] palmitate injected into pregnant guinea pigs was recovered in lipids of their fetuses. From these data and the rate of transport of palmitate in maternal blood, it appears that placental transport of free fatty acids can account for the accumulation of lipids in late gestational fetuses. About 80% of the labeled palmitate in the fetus appeared initially in lipids of the liver. 14C appeared in plasma triglyceride fatty acids after a few minutes and subsequently accumulated in lipids of white and brown adipose tissue, suggesting that much of the palmitate deposited in adipose tissue were derived from hepatogenous triglyceride fatty acids. By contrast, 14C was usually maximal in heart and carcass lipids before it appeared in plasma triglyceride fatty acids. Lipoprotein lipase activity in fetal adipose tissue was low, and activity of cofactor protein of lipoprotein lipase in fetal blood plasma was much lower than that observed in other mammalian species. On the basis of these and earlier observations, it is concluded that the accumulation of triglycerides in liver and blood plasma of fetal guinea pigs during late gestation is at least partly the result of the large uptake of maternally derived free fatty acids by the fetal liver accompanied by rapid synthesis and secretion of triglyceride-rich very low density lipoproteins into the blood. However, limited uptake of triglyceride fatty acids in adipose tissue may contribute to the fatty liver and hyperlipemia.http://www.sciencedirect.com/science/article/pii/S0022227520344965 |
| spellingShingle | T Bohmer R J Havel Genesis of fatty liver and hyperlipemia in the fetal guinea pig. Journal of Lipid Research |
| title | Genesis of fatty liver and hyperlipemia in the fetal guinea pig. |
| title_full | Genesis of fatty liver and hyperlipemia in the fetal guinea pig. |
| title_fullStr | Genesis of fatty liver and hyperlipemia in the fetal guinea pig. |
| title_full_unstemmed | Genesis of fatty liver and hyperlipemia in the fetal guinea pig. |
| title_short | Genesis of fatty liver and hyperlipemia in the fetal guinea pig. |
| title_sort | genesis of fatty liver and hyperlipemia in the fetal guinea pig |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520344965 |
| work_keys_str_mv | AT tbohmer genesisoffattyliverandhyperlipemiainthefetalguineapig AT rjhavel genesisoffattyliverandhyperlipemiainthefetalguineapig |