The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with Preeklampsia
Purpose: We aimed to investigate the relationship between first trimester vitamin D, vitamin B12 and ferritin levels with preeclampsia and neonatal outcomes. Materials and Methods: 191 patients diagnosed with preeclampsia (PE) and 99 healthy pregnant women were included in the study.. Age, gravid...
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| Format: | Article |
| Language: | English |
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Kirsehir Ahi Evran University
2021-12-01
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| Series: | Ahi Evran Medical Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1523816 |
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| author | Selim GÜLÜCÜ Mehmet GÜÇLÜ Sebahattin ÇELİK İlkin Seda CAN Canan SOYER ÇALIŞKAN Samettin ÇELİK |
| author_facet | Selim GÜLÜCÜ Mehmet GÜÇLÜ Sebahattin ÇELİK İlkin Seda CAN Canan SOYER ÇALIŞKAN Samettin ÇELİK |
| author_sort | Selim GÜLÜCÜ |
| collection | DOAJ |
| description | Purpose: We aimed to investigate the relationship between first trimester vitamin D, vitamin B12 and ferritin levels with preeclampsia and
neonatal outcomes.
Materials and Methods: 191 patients diagnosed with preeclampsia (PE) and 99 healthy pregnant women were included in the study.. Age,
gravida, parity, body mass index (BMI), mode of delivery, birth weight, APGAR score, neonatal intensive care unit (NICU) admission and
delivery week were recorded. First trimester vitamin D, vitamin B12 and ferritin levels were determined in laboratory analyzes. Evaluation
was made by separating three groups as without PE, with PE and with severe PE.
Results: Differences were found between BMI measurements, birth weeks, birth weights and NICU acceptance values (p=0.003; 0.001; 0.001;
0.001 respectively). Babies in the PE group had lower mean birth weeks, birth weights and APGAR scores. In the PE group had a higher rate
of cesarean section (p=0.001). The vitamin D level of the PE group was lower than the group without PE. It was found that the vitamin D level
decreased in proportion to the severity of PE. The B12 level of the non-PE group was higher than PE group (p=0.001). The ferritin level of
the non-PE group was found to be lower than the PE group (p=0.001).
Conclusion: Low vitamin D and B12 levels and high ferritin levels in the first trimester may be beneficial in predicting preeclampsia. We
think that especially vitamin D, B12 and iron supplementation is a simple but effective approach to reduce perinatal morbidity and mortality
in preeclampsia.
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| first_indexed | 2024-04-10T10:41:09Z |
| format | Article |
| id | doaj.art-764c742b2d714d078665ea05917f8ae7 |
| institution | Directory Open Access Journal |
| issn | 2619-9203 |
| language | English |
| last_indexed | 2024-04-10T10:41:09Z |
| publishDate | 2021-12-01 |
| publisher | Kirsehir Ahi Evran University |
| record_format | Article |
| series | Ahi Evran Medical Journal |
| spelling | doaj.art-764c742b2d714d078665ea05917f8ae72023-02-15T16:20:33ZengKirsehir Ahi Evran UniversityAhi Evran Medical Journal2619-92032021-12-0153229235https://doi.org/10.46332/aemj.865619The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with PreeklampsiaSelim GÜLÜCÜ0https://orcid.org/0000-0001-7494-4045Mehmet GÜÇLÜ1https://orcid.org/0000-0002-8295-0629Sebahattin ÇELİK2https://orcid.org/0000-0002-2631-1603İlkin Seda CAN3https://orcid.org/0000-0002-2029-7281Canan SOYER ÇALIŞKAN4https://orcid.org/0000-0002-9889-5249Samettin ÇELİK5https://orcid.org/0000-0002-6407-1129Tokat Gaziosmanpaşa ÜniversitesiİSTANBUL SAĞLIK BAKANLIĞI MARMARA ÜNİVERSİTESİ PENDİK EĞİTİM VE ARAŞTIRMA HASTANESİBALIKESİR DEVLET HASTANESİCUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİSAMSUN EĞİTİM VE ARAŞTIRMA HASTANESİSAMSUN EĞİTİM VE ARAŞTIRMA HASTANESİPurpose: We aimed to investigate the relationship between first trimester vitamin D, vitamin B12 and ferritin levels with preeclampsia and neonatal outcomes. Materials and Methods: 191 patients diagnosed with preeclampsia (PE) and 99 healthy pregnant women were included in the study.. Age, gravida, parity, body mass index (BMI), mode of delivery, birth weight, APGAR score, neonatal intensive care unit (NICU) admission and delivery week were recorded. First trimester vitamin D, vitamin B12 and ferritin levels were determined in laboratory analyzes. Evaluation was made by separating three groups as without PE, with PE and with severe PE. Results: Differences were found between BMI measurements, birth weeks, birth weights and NICU acceptance values (p=0.003; 0.001; 0.001; 0.001 respectively). Babies in the PE group had lower mean birth weeks, birth weights and APGAR scores. In the PE group had a higher rate of cesarean section (p=0.001). The vitamin D level of the PE group was lower than the group without PE. It was found that the vitamin D level decreased in proportion to the severity of PE. The B12 level of the non-PE group was higher than PE group (p=0.001). The ferritin level of the non-PE group was found to be lower than the PE group (p=0.001). Conclusion: Low vitamin D and B12 levels and high ferritin levels in the first trimester may be beneficial in predicting preeclampsia. We think that especially vitamin D, B12 and iron supplementation is a simple but effective approach to reduce perinatal morbidity and mortality in preeclampsia. https://dergipark.org.tr/tr/download/article-file/1523816ferritinnewbornpreeclampsiavitamin dvitamin b12 |
| spellingShingle | Selim GÜLÜCÜ Mehmet GÜÇLÜ Sebahattin ÇELİK İlkin Seda CAN Canan SOYER ÇALIŞKAN Samettin ÇELİK The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with Preeklampsia Ahi Evran Medical Journal ferritin newborn preeclampsia vitamin d vitamin b12 |
| title | The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with Preeklampsia |
| title_full | The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with Preeklampsia |
| title_fullStr | The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with Preeklampsia |
| title_full_unstemmed | The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with Preeklampsia |
| title_short | The Relationship of First Trimester Vitamin D, Vitamin B12 and Ferritin Levels with Preeklampsia |
| title_sort | relationship of first trimester vitamin d vitamin b12 and ferritin levels with preeklampsia |
| topic | ferritin newborn preeclampsia vitamin d vitamin b12 |
| url | https://dergipark.org.tr/tr/download/article-file/1523816 |
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