Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort study
Introduction: Vitamin D deficiency in women may play a role in the pathogenesis of infertility and menstrual dysfunction. Due to the high percentage of insufficient vitamin D serum levels in women of reproductive age, recently the role of vitamin D in reproductive physiology has also been considered...
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| Format: | Article |
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Mashhad University of Medical Sciences
2023-05-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_22597_331b95b6bac9fd72c57a949844cefea5.pdf |
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| author | Somayeh Abdolalipour Mahsa Rouhi Shirin Osouli Tabrizi Elaheh rezazadeh Kobra Hamdi Neda Nikkhesal Mojgan Mirghafourvand |
| author_facet | Somayeh Abdolalipour Mahsa Rouhi Shirin Osouli Tabrizi Elaheh rezazadeh Kobra Hamdi Neda Nikkhesal Mojgan Mirghafourvand |
| author_sort | Somayeh Abdolalipour |
| collection | DOAJ |
| description | Introduction: Vitamin D deficiency in women may play a role in the pathogenesis of infertility and menstrual dysfunction. Due to the high percentage of insufficient vitamin D serum levels in women of reproductive age, recently the role of vitamin D in reproductive physiology has also been considered. The present study was performed with aim to determine the relationship between vitamin D serum level and pregnancy success rate in a cycle of in vitro fertilization (IVF).
Methods: In this prospective cohort study conducted in 2022, 116 reproductive-aged women diagnosed with both primary or secondary infertility in their first IVF cycle were studied. Based on the serum level of vitamin D in the blood sample measured by the Elisa method 7 days before embryo transfer, the participants were divided into two groups: deficiency or insufficient and sufficient and were evaluated at the gestational age of 7 weeks in terms of the presence of intrauterine gestational sac and the presence of heartbeat. Data collection tools included socio-demographic, infertility, and nutrition questionnaires, and checklists for recording test results and pregnancy outcomes. Data were analyzed by SPSS statistical software (version 24) and chi-square, independent t-test, and multivariate logistic regression. P<0.05 was considered statistically significant.
Results: The mean of vitamin D serum level in people with successful pregnancy and unsuccessful pregnancy was 60.3±26.8 and 66.5±37.4, respectively (p=0.361) and the frequency of pregnancy success in vitamin D sufficient and insufficient group was 23.3% and 13.6%, respectively (p=0.247). Based on multivariate logistic regression and adjusting for confounding variables, there was no statistically significant difference between the groups in terms of pregnancy success rate (odds ratio: 2.08; 95% (CI): 0.45 to 9.5; (p=0.346).
Conclusion: Although vitamin D serum level in infertile women with successful pregnancies was more than in women with unsuccessful pregnancies, however, this difference was not significant. |
| first_indexed | 2024-03-13T03:15:03Z |
| format | Article |
| id | doaj.art-764c8ca41e704f9aa23ea0cfa31f9867 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-03-13T03:15:03Z |
| publishDate | 2023-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-764c8ca41e704f9aa23ea0cfa31f98672023-06-26T04:29:49ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632023-05-01263334210.22038/ijogi.2023.2259722597Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort studySomayeh Abdolalipour0Mahsa Rouhi1Shirin Osouli Tabrizi2Elaheh rezazadeh3Kobra Hamdi4Neda Nikkhesal5Mojgan Mirghafourvand6PhD student of Midwifery, Students Research Committee, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.M.Sc. of Midwifery, Students Research Committee, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.M.Sc. of Midwifery, Students Research Committee, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.B.Sc. of Midwifery, Islamic Azad University, Tabriz Branch, Tabriz, Iran.Professor, Department of Obstetrics and Gynecology, Women's Reproductive Health Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.M.Sc. of Midwifery, Students Research Committee, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.Professor, Department of Midwifery, Social Determinants of Health Research Center, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.Introduction: Vitamin D deficiency in women may play a role in the pathogenesis of infertility and menstrual dysfunction. Due to the high percentage of insufficient vitamin D serum levels in women of reproductive age, recently the role of vitamin D in reproductive physiology has also been considered. The present study was performed with aim to determine the relationship between vitamin D serum level and pregnancy success rate in a cycle of in vitro fertilization (IVF). Methods: In this prospective cohort study conducted in 2022, 116 reproductive-aged women diagnosed with both primary or secondary infertility in their first IVF cycle were studied. Based on the serum level of vitamin D in the blood sample measured by the Elisa method 7 days before embryo transfer, the participants were divided into two groups: deficiency or insufficient and sufficient and were evaluated at the gestational age of 7 weeks in terms of the presence of intrauterine gestational sac and the presence of heartbeat. Data collection tools included socio-demographic, infertility, and nutrition questionnaires, and checklists for recording test results and pregnancy outcomes. Data were analyzed by SPSS statistical software (version 24) and chi-square, independent t-test, and multivariate logistic regression. P<0.05 was considered statistically significant. Results: The mean of vitamin D serum level in people with successful pregnancy and unsuccessful pregnancy was 60.3±26.8 and 66.5±37.4, respectively (p=0.361) and the frequency of pregnancy success in vitamin D sufficient and insufficient group was 23.3% and 13.6%, respectively (p=0.247). Based on multivariate logistic regression and adjusting for confounding variables, there was no statistically significant difference between the groups in terms of pregnancy success rate (odds ratio: 2.08; 95% (CI): 0.45 to 9.5; (p=0.346). Conclusion: Although vitamin D serum level in infertile women with successful pregnancies was more than in women with unsuccessful pregnancies, however, this difference was not significant.https://ijogi.mums.ac.ir/article_22597_331b95b6bac9fd72c57a949844cefea5.pdfinfertilityin vitro fertilization (ivf)vitamin d |
| spellingShingle | Somayeh Abdolalipour Mahsa Rouhi Shirin Osouli Tabrizi Elaheh rezazadeh Kobra Hamdi Neda Nikkhesal Mojgan Mirghafourvand Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort study Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān infertility in vitro fertilization (ivf) vitamin d |
| title | Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort study |
| title_full | Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort study |
| title_fullStr | Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort study |
| title_full_unstemmed | Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort study |
| title_short | Relationship between serum levels of vitamin D and the success rate of pregnancy in an in vitro fertilization cycle (IVF): A prospective cohort study |
| title_sort | relationship between serum levels of vitamin d and the success rate of pregnancy in an in vitro fertilization cycle ivf a prospective cohort study |
| topic | infertility in vitro fertilization (ivf) vitamin d |
| url | https://ijogi.mums.ac.ir/article_22597_331b95b6bac9fd72c57a949844cefea5.pdf |
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