CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
Abstract. The aim of this study was to investigate some characteristics of neutrophils and monocytes in patients with acute leukemia, depending on presence of an infectious syndrome, as based on studying of CD16, CD64, HLA-DR receptors, along with assaying myeloperoxidase (MPO) and functional activi...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/648 |
| _version_ | 1797198024741486592 |
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| author | S. V. Plotnikova L. F. Aznabaeva G. Sh. Safuanova |
| author_facet | S. V. Plotnikova L. F. Aznabaeva G. Sh. Safuanova |
| author_sort | S. V. Plotnikova |
| collection | DOAJ |
| description | Abstract. The aim of this study was to investigate some characteristics of neutrophils and monocytes in patients with acute leukemia, depending on presence of an infectious syndrome, as based on studying of CD16, CD64, HLA-DR receptors, along with assaying myeloperoxidase (MPO) and functional activity of the cells. Infectious syndrome in acute leukemia patients was accompanied by changes in antibody-dependent cytotoxicity against neutrophils (decreased CD16 and increase in CD64 expression), lower phagocytic capacity of the cells, and myeloperoxidase deficiency of neutrophils and monocytes. In patients with inflammatory manifestations of infectious syndrome (i.e., acute tonsillitis, bronchitis, pneumonia, etc.), the signs of neutrophilic insussiciency were more pronounced, i.e., CD16+ neutrophils comprised 24.36±7.43%, as compared with 74.21±5.43% in controls, p < 0.001; MPO positivity was detected in 29.15±12.6% of the cells against 96.1±1.94% in controls, p < 0.01; MPO expression: 5.34±3.07 MFI, with 32.9±10.76 in controls, p < 0,05. These data suggest significant disturbances of anti-infectious elimination mechanisms. |
| first_indexed | 2024-03-08T05:49:46Z |
| format | Article |
| id | doaj.art-764cb34163d343b488bfa3108d381f16 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:17Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-764cb34163d343b488bfa3108d381f162024-04-22T13:07:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0115436937410.15789/1563-0625-2013-4-369-374645CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROMES. V. Plotnikova0L. F. Aznabaeva1G. Sh. Safuanova2Bashkir State Medical University, Russian Ministry of Health Care, UfaBashkir State Medical University, Russian Ministry of Health Care, UfaBashkir State Medical University, Russian Ministry of Health Care, UfaAbstract. The aim of this study was to investigate some characteristics of neutrophils and monocytes in patients with acute leukemia, depending on presence of an infectious syndrome, as based on studying of CD16, CD64, HLA-DR receptors, along with assaying myeloperoxidase (MPO) and functional activity of the cells. Infectious syndrome in acute leukemia patients was accompanied by changes in antibody-dependent cytotoxicity against neutrophils (decreased CD16 and increase in CD64 expression), lower phagocytic capacity of the cells, and myeloperoxidase deficiency of neutrophils and monocytes. In patients with inflammatory manifestations of infectious syndrome (i.e., acute tonsillitis, bronchitis, pneumonia, etc.), the signs of neutrophilic insussiciency were more pronounced, i.e., CD16+ neutrophils comprised 24.36±7.43%, as compared with 74.21±5.43% in controls, p < 0.001; MPO positivity was detected in 29.15±12.6% of the cells against 96.1±1.94% in controls, p < 0.01; MPO expression: 5.34±3.07 MFI, with 32.9±10.76 in controls, p < 0,05. These data suggest significant disturbances of anti-infectious elimination mechanisms.https://www.mimmun.ru/mimmun/article/view/648neutrophilsmonocytesdifferentiation clustersacute leukemiainfectious complications |
| spellingShingle | S. V. Plotnikova L. F. Aznabaeva G. Sh. Safuanova CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME Медицинская иммунология neutrophils monocytes differentiation clusters acute leukemia infectious complications |
| title | CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME |
| title_full | CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME |
| title_fullStr | CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME |
| title_full_unstemmed | CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME |
| title_short | CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME |
| title_sort | characteristics of phagocytic cells in patients with acute leukemia with an infectious syndrome |
| topic | neutrophils monocytes differentiation clusters acute leukemia infectious complications |
| url | https://www.mimmun.ru/mimmun/article/view/648 |
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