Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries

Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries

Background: Epidemiological studies observed gender differences in COVID-19 outcomes, however, whether sex hormone plays a causal in COVID-19 risk remains unclear. This study aimed to examine associations of sex hormone, sex hormones-binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), and...

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Bibliographic Details
Main Authors: Xinxuan Li, Yajing Zhou, Shuai Yuan, Xuan Zhou, Lijuan Wang, Jing Sun, Lili Yu, Jinghan Zhu, Han Zhang, Nan Yang, Shuhui Dai, Peige Song, Susanna C Larsson, Evropi Theodoratou, Yimin Zhu, Xue Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
sex hormones
IGF-1
COVID-19
Mendelian randomization
Online Access:https://elifesciences.org/articles/79720

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