Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapie...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00120/full |
| _version_ | 1818596197098586112 |
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| author | Raval eMihir Dinesh eBande Anil Kumar Pillai Lawrence S Blaszkowsky Suvranu eGanguli Muhammad S Beg Sanjeeva P Kalva |
| author_facet | Raval eMihir Dinesh eBande Anil Kumar Pillai Lawrence S Blaszkowsky Suvranu eGanguli Muhammad S Beg Sanjeeva P Kalva |
| author_sort | Raval eMihir |
| collection | DOAJ |
| description | Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies are increasingly being utilized. Yttrium-90 (Y-90) microsphere therapy, also known as selective internal radiation therapy (SIRT) or radioembolization, has proven to be effective in terms of extending time to progression of disease and also providing survival benefit. This review focuses on the use of Y-90 microsphere therapy in the treatment of liver metastases from CRC, including a comprehensive review of published clinical trials and prospective studies conducted thus far. We review the methodology, outcomes and side effects of Y-90 microsphere therapy for metastatic CRC |
| first_indexed | 2024-12-16T11:28:05Z |
| format | Article |
| id | doaj.art-764f6a58c3ad405eb61882a15ddfb84a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T11:28:05Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-764f6a58c3ad405eb61882a15ddfb84a2022-12-21T22:33:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-07-01410.3389/fonc.2014.0012082383Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal CancerRaval eMihir0Dinesh eBande1Anil Kumar Pillai2Lawrence S Blaszkowsky3Suvranu eGanguli4Muhammad S Beg5Sanjeeva P Kalva6Essentia HealthSanford HealthUniversity of Texas Southwestern Medical CenterMassachusetts General Hospital, Boston, MAMassachusetts General HospitalUT Southwestern Medical Center, Dallas, TXUniversity of Texas Southwestern Medical CenterLiver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies are increasingly being utilized. Yttrium-90 (Y-90) microsphere therapy, also known as selective internal radiation therapy (SIRT) or radioembolization, has proven to be effective in terms of extending time to progression of disease and also providing survival benefit. This review focuses on the use of Y-90 microsphere therapy in the treatment of liver metastases from CRC, including a comprehensive review of published clinical trials and prospective studies conducted thus far. We review the methodology, outcomes and side effects of Y-90 microsphere therapy for metastatic CRChttp://journal.frontiersin.org/Journal/10.3389/fonc.2014.00120/fullcolorectal cancerliver metastasesRadioembolizationselective internal radiation therapyYttrium-90 microspheresY90 therapy |
| spellingShingle | Raval eMihir Dinesh eBande Anil Kumar Pillai Lawrence S Blaszkowsky Suvranu eGanguli Muhammad S Beg Sanjeeva P Kalva Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer Frontiers in Oncology colorectal cancer liver metastases Radioembolization selective internal radiation therapy Yttrium-90 microspheres Y90 therapy |
| title | Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer |
| title_full | Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer |
| title_fullStr | Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer |
| title_full_unstemmed | Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer |
| title_short | Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer |
| title_sort | yttrium 90 radioembolization of hepatic metastases from colorectal cancer |
| topic | colorectal cancer liver metastases Radioembolization selective internal radiation therapy Yttrium-90 microspheres Y90 therapy |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00120/full |
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