MicroRNAs in Metastasis and the Tumour Microenvironment
Metastasis is the process whereby cancer cells migrate from the primary tumour site to colonise the surrounding or distant tissue or organ. Metastasis is the primary cause of cancer-related mortality and approximately half of all cancer patients present at diagnosis with some form of metastasis. Con...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/9/4859 |
| _version_ | 1797535291321352192 |
|---|---|
| author | Carla Solé Charles Henderson Lawrie |
| author_facet | Carla Solé Charles Henderson Lawrie |
| author_sort | Carla Solé |
| collection | DOAJ |
| description | Metastasis is the process whereby cancer cells migrate from the primary tumour site to colonise the surrounding or distant tissue or organ. Metastasis is the primary cause of cancer-related mortality and approximately half of all cancer patients present at diagnosis with some form of metastasis. Consequently, there is a clear need to better understand metastasis in order to develop new tools to combat this process. MicroRNAs (miRNAs) regulate gene expression and play an important role in cancer development and progression including in the metastatic process. Particularly important are the roles that miRNAs play in the interaction between tumour cells and non-tumoral cells of the tumour microenvironment (TME), a process mediated largely by circulating miRNAs contained primarily in extracellular vesicles (EVs). In this review, we outline the accumulating evidence for the importance of miRNAs in the communication between tumour cells and the cells of the TME in the context of the pre-metastatic and metastatic niche. |
| first_indexed | 2024-03-10T11:43:26Z |
| format | Article |
| id | doaj.art-7652d5538dab4f4cb0c37a2e2f6b2d20 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:43:26Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7652d5538dab4f4cb0c37a2e2f6b2d202023-11-21T18:19:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01229485910.3390/ijms22094859MicroRNAs in Metastasis and the Tumour MicroenvironmentCarla Solé0Charles Henderson Lawrie1Molecular Oncology Group, Biodonostia Research Institute, 20014 San Sebastian, SpainMolecular Oncology Group, Biodonostia Research Institute, 20014 San Sebastian, SpainMetastasis is the process whereby cancer cells migrate from the primary tumour site to colonise the surrounding or distant tissue or organ. Metastasis is the primary cause of cancer-related mortality and approximately half of all cancer patients present at diagnosis with some form of metastasis. Consequently, there is a clear need to better understand metastasis in order to develop new tools to combat this process. MicroRNAs (miRNAs) regulate gene expression and play an important role in cancer development and progression including in the metastatic process. Particularly important are the roles that miRNAs play in the interaction between tumour cells and non-tumoral cells of the tumour microenvironment (TME), a process mediated largely by circulating miRNAs contained primarily in extracellular vesicles (EVs). In this review, we outline the accumulating evidence for the importance of miRNAs in the communication between tumour cells and the cells of the TME in the context of the pre-metastatic and metastatic niche.https://www.mdpi.com/1422-0067/22/9/4859tumour microenvironmentmiRNAsmetastasis |
| spellingShingle | Carla Solé Charles Henderson Lawrie MicroRNAs in Metastasis and the Tumour Microenvironment International Journal of Molecular Sciences tumour microenvironment miRNAs metastasis |
| title | MicroRNAs in Metastasis and the Tumour Microenvironment |
| title_full | MicroRNAs in Metastasis and the Tumour Microenvironment |
| title_fullStr | MicroRNAs in Metastasis and the Tumour Microenvironment |
| title_full_unstemmed | MicroRNAs in Metastasis and the Tumour Microenvironment |
| title_short | MicroRNAs in Metastasis and the Tumour Microenvironment |
| title_sort | micrornas in metastasis and the tumour microenvironment |
| topic | tumour microenvironment miRNAs metastasis |
| url | https://www.mdpi.com/1422-0067/22/9/4859 |
| work_keys_str_mv | AT carlasole micrornasinmetastasisandthetumourmicroenvironment AT charleshendersonlawrie micrornasinmetastasisandthetumourmicroenvironment |