High Myopia and the Complement System: Factor H in Myopic Maculopathy
High myopia (HM) is both a medical problem and refractive error of the eye owing to excessive eyeball length, which progressively makes eye tissue atrophic, and is one of the main causes for diminishing visual acuity in developed countries. Despite its high prevalence and many genetic and proteomic...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/12/2600 |
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| author | Enrique García-Gen Mariola Penadés Salvador Mérida Carmen Desco Rafael Araujo-Miranda Amparo Navea F. Bosch-Morell |
| author_facet | Enrique García-Gen Mariola Penadés Salvador Mérida Carmen Desco Rafael Araujo-Miranda Amparo Navea F. Bosch-Morell |
| author_sort | Enrique García-Gen |
| collection | DOAJ |
| description | High myopia (HM) is both a medical problem and refractive error of the eye owing to excessive eyeball length, which progressively makes eye tissue atrophic, and is one of the main causes for diminishing visual acuity in developed countries. Despite its high prevalence and many genetic and proteomic studies, no molecular pattern exists that explain the degenerative process underlying HM, which predisposes patients to other diseases like glaucoma, cataracts, retinal detachment and chorioretinal atrophy that affect the macular area. To determine the relation between complement Factors H (CFH) and D (CFD) and the maculopathy of patients with degenerative myopia, we studied aqueous humor samples that were collected by aspiration from 122 patients during cataract surgery. Eyes were classified according to eyeball axial length as high myopia (axial length > 26 mm), low myopia (axial length 23.5–25.9 mm) and control (axial length ˂ 23.4 mm). The degree of maculopathy was classified according to fundus oculi findings following IMI’s classification. Subfoveal choroid thickness was measured by optical coherence tomography. CFH and CFD measurements were taken by ELISA. CFH levels were significantly high in the high myopia group vs. the low myopia and control groups (<i>p</i> ˂ 0.05). Significantly high CFH values were found in those eyes with choroid atrophy and neovascularization (<i>p</i> ˂ 0.05). In parallel, the CFH concentration correlated inversely with choroid thickness (R = −0.624). CFD levels did not correlate with maculopathy. All the obtained data seem to suggest that CFH plays a key role in myopic pathology. |
| first_indexed | 2024-03-10T10:28:19Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T10:28:19Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-76566a7b672344c292cd1514707b92102023-11-21T23:51:01ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011012260010.3390/jcm10122600High Myopia and the Complement System: Factor H in Myopic MaculopathyEnrique García-Gen0Mariola Penadés1Salvador Mérida2Carmen Desco3Rafael Araujo-Miranda4Amparo Navea5F. Bosch-Morell6Departamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, CEU Universities, 46115 Valencia, SpainDepartamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, CEU Universities, 46115 Valencia, SpainDepartamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, CEU Universities, 46115 Valencia, SpainDepartamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, CEU Universities, 46115 Valencia, SpainFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), 46020 València, SpainDepartamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, CEU Universities, 46115 Valencia, SpainDepartamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, CEU Universities, 46115 Valencia, SpainHigh myopia (HM) is both a medical problem and refractive error of the eye owing to excessive eyeball length, which progressively makes eye tissue atrophic, and is one of the main causes for diminishing visual acuity in developed countries. Despite its high prevalence and many genetic and proteomic studies, no molecular pattern exists that explain the degenerative process underlying HM, which predisposes patients to other diseases like glaucoma, cataracts, retinal detachment and chorioretinal atrophy that affect the macular area. To determine the relation between complement Factors H (CFH) and D (CFD) and the maculopathy of patients with degenerative myopia, we studied aqueous humor samples that were collected by aspiration from 122 patients during cataract surgery. Eyes were classified according to eyeball axial length as high myopia (axial length > 26 mm), low myopia (axial length 23.5–25.9 mm) and control (axial length ˂ 23.4 mm). The degree of maculopathy was classified according to fundus oculi findings following IMI’s classification. Subfoveal choroid thickness was measured by optical coherence tomography. CFH and CFD measurements were taken by ELISA. CFH levels were significantly high in the high myopia group vs. the low myopia and control groups (<i>p</i> ˂ 0.05). Significantly high CFH values were found in those eyes with choroid atrophy and neovascularization (<i>p</i> ˂ 0.05). In parallel, the CFH concentration correlated inversely with choroid thickness (R = −0.624). CFD levels did not correlate with maculopathy. All the obtained data seem to suggest that CFH plays a key role in myopic pathology.https://www.mdpi.com/2077-0383/10/12/2600high myopiaaqueous humor samplescomplement factor Hchoroid thicknessmaculopathy |
| spellingShingle | Enrique García-Gen Mariola Penadés Salvador Mérida Carmen Desco Rafael Araujo-Miranda Amparo Navea F. Bosch-Morell High Myopia and the Complement System: Factor H in Myopic Maculopathy Journal of Clinical Medicine high myopia aqueous humor samples complement factor H choroid thickness maculopathy |
| title | High Myopia and the Complement System: Factor H in Myopic Maculopathy |
| title_full | High Myopia and the Complement System: Factor H in Myopic Maculopathy |
| title_fullStr | High Myopia and the Complement System: Factor H in Myopic Maculopathy |
| title_full_unstemmed | High Myopia and the Complement System: Factor H in Myopic Maculopathy |
| title_short | High Myopia and the Complement System: Factor H in Myopic Maculopathy |
| title_sort | high myopia and the complement system factor h in myopic maculopathy |
| topic | high myopia aqueous humor samples complement factor H choroid thickness maculopathy |
| url | https://www.mdpi.com/2077-0383/10/12/2600 |
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