Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation

Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases. Alarmins, also known as damage-associated molecular patterns, are released in the presence of neuroinflammation and in the acute phase of ischemia. Defe...

Full description

Bibliographic Details
Main Authors:	Nina D. Anfinogenova, Mark T. Quinn, Igor A. Schepetkin, Dmitriy N. Atochin
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Cells
Subjects:	alarmin neuroinflammation Alzheimer’s disease microglia c-Jun N-terminal kinase high-mobility group box protein 1
Online Access:	https://www.mdpi.com/2073-4409/9/11/2350

Similar Items

Novel Tryptanthrin Derivatives with Selectivity as <i>c</i>–Jun N–Terminal Kinase (JNK) 3 Inhibitors
by: Igor A. Schepetkin, et al.
Published: (2023-06-01)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats
by: Mark B. Plotnikov, et al.
Published: (2019-05-01)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
by: Justin Hou Ming Yung, et al.
Published: (2020-03-01)

Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis
by: Benjamin Lai, et al.
Published: (2020-11-01)

Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain
by: Rahat Ullah, et al.
Published: (2020-12-01)

Fish c-Jun N-Terminal Kinase (JNK) Pathway Is Involved in Bacterial MDP-Induced Intestinal Inflammation
by: Fufa Qu, et al.
Published: (2020-03-01)

c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases
by: Stephanie Cristine Hepp Rehfeldt, et al.
Published: (2020-12-01)

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
by: Men Thi Hoai Duong, et al.
Published: (2020-01-01)

Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia
by: Mark B. Plotnikov, et al.
Published: (2020-08-01)

Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction
by: Mark B. Plotnikov, et al.
Published: (2023-02-01)

Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells[S]
by: Jun Ma, et al.
Published: (2012-06-01)

Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one Scaffold
by: Serhii A. Liakhov, et al.
Published: (2021-09-01)

MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus
by: Barbara Vacca, et al.
Published: (2016-11-01)

Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats
by: Wang Xiao-Wei, et al.
Published: (2012-06-01)

Involvement of Alarmins in the Pathogenesis and Progression of Multiple Myeloma
by: Giuseppe Murdaca, et al.
Published: (2021-08-01)

Schizophrenia and Alarmins
by: Huan Ma, et al.
Published: (2022-05-01)

A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies
by: Hyunwook Cho, et al.
Published: (2021-10-01)

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors
by: Igor A. Schepetkin, et al.
Published: (2022-09-01)

c-Jun Amino Terminal Kinase Signaling Promotes Aristolochic Acid-Induced Acute Kidney Injury
by: Fan Yang, et al.
Published: (2021-02-01)

Suppression of Age-Related Macular Degeneration-like Pathology by c-Jun N-Terminal Kinase Inhibitor IQ-1S
by: Anna A. Zhdankina, et al.
Published: (2023-01-01)

The Jun N-terminal kinases signaling pathway plays a “seesaw” role in ovarian carcinoma: a molecular aspect
by: Yingyu Dou, et al.
Published: (2019-10-01)

Anti-high-mobility group box-1 (HMGB1) mediates the apoptosis of alveolar epithelial cells (AEC) by receptor of advanced glycation end-products (RAGE)/c-Jun N-terminal kinase (JNK) pathway in the rats of crush injuries
by: Bin-Fei Zhang, et al.
Published: (2022-01-01)

Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal KinasesSummary
by: Zhigang Fang, et al.
Published: (2021-01-01)

c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway
by: Rong-Rong Wang, et al.
Published: (2019-01-01)

Pro-apoptotic and pro-proliferation functions of the JNK pathway of Drosophila: roles in cell competition, tumorigenesis and regeneration
by: Noelia Pinal, et al.
Published: (2019-03-01)

Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK
by: Eun Su Jeon, et al.
Published: (2006-03-01)

Corrigendum: c-Jun amino terminal kinase signaling promotes aristolochic acid-induced acute kidney injury
by: Fan Yang, et al.
Published: (2023-01-01)

The Multitasking Potential of Alarmins and Atypical Chemokines
by: Aphrodite Kapurniotu, et al.
Published: (2019-01-01)

Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons
by: Zhengyu Cao, et al.
Published: (2015-02-01)

Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila
by: Chenxi Wu, et al.
Published: (2015-01-01)

Inhibition of the Phospholipase Cε–c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties
by: Masashi Okada, et al.
Published: (2022-08-01)

Glycine, the smallest amino acid, confers neuroprotection against d-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain
by: Rahat Ullah, et al.
Published: (2020-10-01)

Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells
by: Phuong Linh Nguyen, et al.
Published: (2021-08-01)

Inhibition of Vascular c‐Jun N‐Terminal Kinase 2 Improves Obesity‐Induced Endothelial Dysfunction After Roux‐en‐Y Gastric Bypass
by: Petia Doytcheva, et al.
Published: (2017-11-01)

Sonidegib Suppresses Production of Inflammatory Mediators and Cell Migration in BV2 Microglial Cells and Mice Treated with Lipopolysaccharide via JNK and NF-κB Inhibition
by: Ngoc Minh Nguyen, et al.
Published: (2022-09-01)

Role of Alarmins in the Pathogenesis of Systemic Sclerosis
by: Antonello Giovannetti, et al.
Published: (2020-07-01)

Inositol-requiring enzyme 1α and c-Jun N-terminal kinase axis activation contributes to intracellular lipid accumulation in calf hepatocytes
by: Wenwen Gao, et al.
Published: (2024-05-01)

Effects of lead and manganese combined exposure on neurodevelopmental toxicity and JNK expression in zebrafish
by: Yuan XIA, et al.
Published: (2023-05-01)

Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade
by: Manuel Canedo-Antelo, et al.
Published: (2018-09-01)

Emerging Role of Alarmins in Food Allergy: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications
by: Angela Rizzi, et al.
Published: (2023-04-01)