Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

Abstract Background Chemokine signalling is required for the homing of leukocytes during retinal inflammation, and is associated with pathogenesis of diseases such as age-related macular degeneration (AMD). Here, we explore the role of interleukin-1β (IL-1β) in modulating AMD-associated chemokines C...

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Bibliographic Details
Main Authors: Riccardo Natoli, Nilisha Fernando, Michele Madigan, Joshua A. Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Molecular Neurodegeneration
Subjects:
Retinal degeneration
Microglia
Interleukin-1β
IL-1β
Chemokines
RPE
Online Access:http://link.springer.com/article/10.1186/s13024-017-0175-y

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