Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysis
Background Many studies have been conducted on heart, liver, and endocrine abnormalities in thalassemia; however, studies on pulmonary dysfunction (PD) have been limited. Previous studies on the prevalence of restrictive lung disease (RLD) and obstructive lung disease (OLD) in β-thalassemia major pa...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2022-01-01
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| Series: | Paediatrica Indonesiana |
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| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2523 |
| _version_ | 1818492382672322560 |
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| author | Amar Taksande Yash Dalal Himanshi Jindal Taksande Bharati |
| author_facet | Amar Taksande Yash Dalal Himanshi Jindal Taksande Bharati |
| author_sort | Amar Taksande |
| collection | DOAJ |
| description | Background Many studies have been conducted on heart, liver, and endocrine abnormalities in thalassemia; however, studies on pulmonary dysfunction (PD) have been limited. Previous studies on the prevalence of restrictive lung disease (RLD) and obstructive lung disease (OLD) in β-thalassemia major patients have lacked agreement.
Objective To assess the prevalence of PD in β-thalassemia major patients by systematic review of the literature and meta-analysis.
Methods We searched Cochrane library, PubMed, Web of Science, MEDLINE, Scopus, and Embase for relevant articles. Articles were selected according to the inclusion criteria and data were extracted. The primary outcome was prevalence of pulmonary dysfunction in β-thalassemia major with 95% confidence interval (95%CI). Subgroup analyses were applied to explore the prevalence in different age groups, regions, and serum ferritin levels. Sensitivity analysis and publication bias assessment were also conducted.
Results A total of 37 studies comprising 1,467 cases were included in this analysis. Pulmonary dysfunction was present in 64.7% (95%CI 57.6 to 71.1) of cases. The pooled prevalence of RLD (44.9%) was higher than that of OLD (7.6%) and diffusion impairment (DI) (35.6%). Subgroup analysis revealed that the region with the highest pooled prevalence of PD was the Americas (75.2%). The highest prevalence of RLD and DI was found in Asia (48.2% and 44.6%, respectively) and that of OLD in Europe (9.7%). Sensitivity analysis showed that the pooled results were robust.
Conclusion A high prevalence of pulmonary dysfunction, mainly RLD rather than OLD, was detected in β-thalassemia major patients. |
| first_indexed | 2024-12-10T17:42:18Z |
| format | Article |
| id | doaj.art-765bca75d1a84fbb9ea3045b3f3eec06 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-10T17:42:18Z |
| publishDate | 2022-01-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-765bca75d1a84fbb9ea3045b3f3eec062022-12-22T01:39:19ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2022-01-0162172610.14238/pi62.1.2022.7-262523Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysisAmar Taksande0Yash Dalal1Himanshi Jindal2Taksande Bharati3Department of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra StateDepartment of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra StateDepartment of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra StateDepartment of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra StateBackground Many studies have been conducted on heart, liver, and endocrine abnormalities in thalassemia; however, studies on pulmonary dysfunction (PD) have been limited. Previous studies on the prevalence of restrictive lung disease (RLD) and obstructive lung disease (OLD) in β-thalassemia major patients have lacked agreement. Objective To assess the prevalence of PD in β-thalassemia major patients by systematic review of the literature and meta-analysis. Methods We searched Cochrane library, PubMed, Web of Science, MEDLINE, Scopus, and Embase for relevant articles. Articles were selected according to the inclusion criteria and data were extracted. The primary outcome was prevalence of pulmonary dysfunction in β-thalassemia major with 95% confidence interval (95%CI). Subgroup analyses were applied to explore the prevalence in different age groups, regions, and serum ferritin levels. Sensitivity analysis and publication bias assessment were also conducted. Results A total of 37 studies comprising 1,467 cases were included in this analysis. Pulmonary dysfunction was present in 64.7% (95%CI 57.6 to 71.1) of cases. The pooled prevalence of RLD (44.9%) was higher than that of OLD (7.6%) and diffusion impairment (DI) (35.6%). Subgroup analysis revealed that the region with the highest pooled prevalence of PD was the Americas (75.2%). The highest prevalence of RLD and DI was found in Asia (48.2% and 44.6%, respectively) and that of OLD in Europe (9.7%). Sensitivity analysis showed that the pooled results were robust. Conclusion A high prevalence of pulmonary dysfunction, mainly RLD rather than OLD, was detected in β-thalassemia major patients.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2523thalassemia; pulmonary dysfunction; restrictive; obstructive; iron overload; serum ferritin |
| spellingShingle | Amar Taksande Yash Dalal Himanshi Jindal Taksande Bharati Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysis Paediatrica Indonesiana thalassemia; pulmonary dysfunction; restrictive; obstructive; iron overload; serum ferritin |
| title | Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysis |
| title_full | Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysis |
| title_fullStr | Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysis |
| title_short | Prevalence of pulmonary dysfunction in patients with beta thalassemia major: a systematic review and meta-analysis |
| title_sort | prevalence of pulmonary dysfunction in patients with beta thalassemia major a systematic review and meta analysis |
| topic | thalassemia; pulmonary dysfunction; restrictive; obstructive; iron overload; serum ferritin |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2523 |
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