TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Abstract Background Inclusions of TAR DNA-binding protein 43 kDa (TDP-43) has been designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without co-occurrence of Alzheimer’s disease (AD). Approximately, 30–70% AD cases present TDP-43 proteinopathy (AD-TDP), and a greater d...

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Bibliographic Details
Main Authors: Virginia Estades Ayuso, Sarah Pickles, Tiffany Todd, Mei Yue, Karen Jansen-West, Yuping Song, Jesús González Bejarano, Bailey Rawlinson, Michael DeTure, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, Keith A. Josephs, Leonard Petrucelli, Mercedes Prudencio
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Neurodegeneration
Subjects:
TDP-43
Alzheimer’s disease
Cryptic RNA
LATE
STMN2
Online Access:https://doi.org/10.1186/s13024-023-00646-z

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