Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space
Considering the imminence of long-term space travel, it is necessary to investigate the impact of space microgravity (SPC-µG) in order to determine if this environment has consequences on the astronauts’ health, in particular, neural and cognitive functions. Neural stem cells (NSCs) are the basis fo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14320 |
| _version_ | 1797465034017734656 |
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| author | Sophia Shaka Nicolas Carpo Victoria Tran Carlos Cepeda Araceli Espinosa-Jeffrey |
| author_facet | Sophia Shaka Nicolas Carpo Victoria Tran Carlos Cepeda Araceli Espinosa-Jeffrey |
| author_sort | Sophia Shaka |
| collection | DOAJ |
| description | Considering the imminence of long-term space travel, it is necessary to investigate the impact of space microgravity (SPC-µG) in order to determine if this environment has consequences on the astronauts’ health, in particular, neural and cognitive functions. Neural stem cells (NSCs) are the basis for the regeneration of the central nervous system (CNS) cell populations and learning how weightlessness impacts NSCs in health and disease provides a critical tool for the potential mitigation of specific mechanisms leading to neurological disorders. In previous studies, we found that exposure to SPC-µG resulted in enhanced proliferation, a shortened cell cycle, and a larger cell diameter of NSCs compared to control cells. Here, we report the frequent occurrence of abnormal cell division (ACD) including incomplete cell division (ICD), where cytokinesis is not successfully completed, and multi-daughter cell division (MDCD) of NSCs following SPC-µG as well as secretome exposure compared to ground control (1G) NSCs. These findings provide new insights into the potential health implications of space travel and have far-reaching implications for understanding the mechanisms leading to the deleterious effects of long-term space travel as well as potential carcinogenic susceptibility. Knowledge of these mechanisms could help to develop preventive or corrective measures for successful long-term SPC-µG exposure. |
| first_indexed | 2024-03-09T18:15:46Z |
| format | Article |
| id | doaj.art-765e1c21f3a94fc39cfe26a3e1bfcdd5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:15:46Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-765e1c21f3a94fc39cfe26a3e1bfcdd52023-11-24T08:42:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221432010.3390/ijms232214320Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in SpaceSophia Shaka0Nicolas Carpo1Victoria Tran2Carlos Cepeda3Araceli Espinosa-Jeffrey4Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, The University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, The University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, The University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, The University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, The University of California Los Angeles, Los Angeles, CA 90095, USAConsidering the imminence of long-term space travel, it is necessary to investigate the impact of space microgravity (SPC-µG) in order to determine if this environment has consequences on the astronauts’ health, in particular, neural and cognitive functions. Neural stem cells (NSCs) are the basis for the regeneration of the central nervous system (CNS) cell populations and learning how weightlessness impacts NSCs in health and disease provides a critical tool for the potential mitigation of specific mechanisms leading to neurological disorders. In previous studies, we found that exposure to SPC-µG resulted in enhanced proliferation, a shortened cell cycle, and a larger cell diameter of NSCs compared to control cells. Here, we report the frequent occurrence of abnormal cell division (ACD) including incomplete cell division (ICD), where cytokinesis is not successfully completed, and multi-daughter cell division (MDCD) of NSCs following SPC-µG as well as secretome exposure compared to ground control (1G) NSCs. These findings provide new insights into the potential health implications of space travel and have far-reaching implications for understanding the mechanisms leading to the deleterious effects of long-term space travel as well as potential carcinogenic susceptibility. Knowledge of these mechanisms could help to develop preventive or corrective measures for successful long-term SPC-µG exposure.https://www.mdpi.com/1422-0067/23/22/14320human neural stem cellsabnormal cell divisioncytokinesisgravitational researchbrainmicrogravity |
| spellingShingle | Sophia Shaka Nicolas Carpo Victoria Tran Carlos Cepeda Araceli Espinosa-Jeffrey Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space International Journal of Molecular Sciences human neural stem cells abnormal cell division cytokinesis gravitational research brain microgravity |
| title | Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space |
| title_full | Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space |
| title_fullStr | Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space |
| title_full_unstemmed | Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space |
| title_short | Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space |
| title_sort | space microgravity alters neural stem cell division implications for brain cancer research on earth and in space |
| topic | human neural stem cells abnormal cell division cytokinesis gravitational research brain microgravity |
| url | https://www.mdpi.com/1422-0067/23/22/14320 |
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