Beyond use date of drugs
Context: There are standards that allow establishing the microbiological and physicochemical stability of a medicine; however, beyond use date of drugs depends not only on these criteria, but also on individual institutional characteristics. The multiple factors that involve the allocation of the st...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
GarVal Editorial Ltda.
2018-09-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol6/jppres18.406_6.5.412.pdf |
| _version_ | 1819049561954451456 |
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| author | Laura M. Rendón Sara Lopera Naira Y. Valencia |
| author_facet | Laura M. Rendón Sara Lopera Naira Y. Valencia |
| author_sort | Laura M. Rendón |
| collection | DOAJ |
| description | Context: There are standards that allow establishing the microbiological and physicochemical stability of a medicine; however, beyond use date of drugs depends not only on these criteria, but also on individual institutional characteristics. The multiple factors that involve the allocation of the stability of a medication, if not properly articulated, can lead to therapeutic failures and adverse events in patients.
Aims: To design an algorithm to determine the stability beyond use date of a drug in a high complexity healthcare institution.
Methods: Pharmaceutical form, packaging, and administration route were defined for each drug. Physicochemical and microbiological stability were assigned to each product. An algorithm was built with the collected information. The stability beyond use date was the shortest time registered between microbiological and physicochemical stability, however, the information of the manufacturer was respected.
Results: A total of 938 drugs were analyzed, which 606 (64.6%) were considered as single-dose and 332 (35.4%) as multiple-dose. The mean reason to assign a drug as a single-dose with 90.9% was pharmaceutical form unable to storage, tablet, capsule, and ampoule the most frequent. The main cause with 54.4% to assign a drug as multiple-dose was synthetic products with liquid and semisolid pharmaceutical forms whose packaging materials were allowed to storage after its first use.
Conclusions: An algorithm was designed, which can assign the stability beyond use date of drugs using an easy and reliable, generating a more safety use inside the institution. |
| first_indexed | 2024-12-21T11:34:07Z |
| format | Article |
| id | doaj.art-765fd64d023346f1921ebc31c50308e1 |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-21T11:34:07Z |
| publishDate | 2018-09-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-765fd64d023346f1921ebc31c50308e12022-12-21T19:05:29ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502018-09-0165412423Beyond use date of drugsLaura M. Rendón0Sara Lopera1Naira Y. Valencia2Servicio de Vigilancia Farmacológica, Hospital Universitario de San Vicente Fundación, calle 64 No 51d – 154, Código Postal 050010, Medellín, Colombia. Centro de Información y Estudio de Medicamentos y Tóxicos (CIEMTO), Facultad de Medicina, Universidad de Antioquia, carrera 51d No 62 – 42, Código Postal 050010, Medellín, Colombia.Servicio de Vigilancia Farmacológica, Hospital Universitario de San Vicente Fundación, calle 64 No 51d – 154, Código Postal 050010, Medellín, Colombia.Servicio de Vigilancia Farmacológica, Hospital Universitario de San Vicente Fundación, calle 64 No 51d – 154, Código Postal 050010, Medellín, Colombia. Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, calle 67 No. 53 – 108, Código Postal 050010, Medellín, Colombia.Context: There are standards that allow establishing the microbiological and physicochemical stability of a medicine; however, beyond use date of drugs depends not only on these criteria, but also on individual institutional characteristics. The multiple factors that involve the allocation of the stability of a medication, if not properly articulated, can lead to therapeutic failures and adverse events in patients. Aims: To design an algorithm to determine the stability beyond use date of a drug in a high complexity healthcare institution. Methods: Pharmaceutical form, packaging, and administration route were defined for each drug. Physicochemical and microbiological stability were assigned to each product. An algorithm was built with the collected information. The stability beyond use date was the shortest time registered between microbiological and physicochemical stability, however, the information of the manufacturer was respected. Results: A total of 938 drugs were analyzed, which 606 (64.6%) were considered as single-dose and 332 (35.4%) as multiple-dose. The mean reason to assign a drug as a single-dose with 90.9% was pharmaceutical form unable to storage, tablet, capsule, and ampoule the most frequent. The main cause with 54.4% to assign a drug as multiple-dose was synthetic products with liquid and semisolid pharmaceutical forms whose packaging materials were allowed to storage after its first use. Conclusions: An algorithm was designed, which can assign the stability beyond use date of drugs using an easy and reliable, generating a more safety use inside the institution.http://jppres.com/jppres/pdf/vol6/jppres18.406_6.5.412.pdfdosage formsdrug packagingdrug stabilitydrug storagepharmaceutical preparationspharmaceutical technology |
| spellingShingle | Laura M. Rendón Sara Lopera Naira Y. Valencia Beyond use date of drugs Journal of Pharmacy & Pharmacognosy Research dosage forms drug packaging drug stability drug storage pharmaceutical preparations pharmaceutical technology |
| title | Beyond use date of drugs |
| title_full | Beyond use date of drugs |
| title_fullStr | Beyond use date of drugs |
| title_full_unstemmed | Beyond use date of drugs |
| title_short | Beyond use date of drugs |
| title_sort | beyond use date of drugs |
| topic | dosage forms drug packaging drug stability drug storage pharmaceutical preparations pharmaceutical technology |
| url | http://jppres.com/jppres/pdf/vol6/jppres18.406_6.5.412.pdf |
| work_keys_str_mv | AT lauramrendon beyondusedateofdrugs AT saralopera beyondusedateofdrugs AT nairayvalencia beyondusedateofdrugs |