EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6
Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from...
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| Format: | Article |
| Language: | English |
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IKATAN AHLI UROLOGI INDONESIA
2014-09-01
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| Series: | Jurnal Urologi Indonesia |
| Subjects: | |
| Online Access: | https://juri.urologi.or.id/juri/article/view/341 |
| _version_ | 1828796071810170880 |
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| author | Ramlan Nasution Suwandi Sugandi Aaron Tigor Sihombing Anglita Yantisetiasti Betthy S Hernowo |
| author_facet | Ramlan Nasution Suwandi Sugandi Aaron Tigor Sihombing Anglita Yantisetiasti Betthy S Hernowo |
| author_sort | Ramlan Nasution |
| collection | DOAJ |
| description | Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significant association between antikeratin 34β-E12 staining with age, prostate volume, and leucocyturia. Conclusions: 15 % cases of prostatic cancer Gleason score 6 still showed basal cell existence. Immunohistochemical staining of basal cell should be considered in suspicious cases of prostatic cancer. |
| first_indexed | 2024-12-12T04:15:08Z |
| format | Article |
| id | doaj.art-766275c8aaac4bfa83219cbb0916a3c2 |
| institution | Directory Open Access Journal |
| issn | 0853-442X 2355-1402 |
| language | English |
| last_indexed | 2024-12-12T04:15:08Z |
| publishDate | 2014-09-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj.art-766275c8aaac4bfa83219cbb0916a3c22022-12-22T00:38:28ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022014-09-0117110.32421/juri.v17i1.341341EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6Ramlan Nasution0Suwandi Sugandi1Aaron Tigor Sihombing2Anglita Yantisetiasti3Betthy S Hernowo4Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital. Jl. Pasteur No. 38 BandungDepartment of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital. Jl. Pasteur No. 38 BandungDepartment of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital. Jl. Pasteur No. 38 BandungDepartment of Anatomical Pathology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.Department of Anatomical Pathology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significant association between antikeratin 34β-E12 staining with age, prostate volume, and leucocyturia. Conclusions: 15 % cases of prostatic cancer Gleason score 6 still showed basal cell existence. Immunohistochemical staining of basal cell should be considered in suspicious cases of prostatic cancer.https://juri.urologi.or.id/juri/article/view/341Gleason score 6 prostate cancerbasal cellantikeratin 34β-E12 |
| spellingShingle | Ramlan Nasution Suwandi Sugandi Aaron Tigor Sihombing Anglita Yantisetiasti Betthy S Hernowo EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 Jurnal Urologi Indonesia Gleason score 6 prostate cancer basal cell antikeratin 34β-E12 |
| title | EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 |
| title_full | EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 |
| title_fullStr | EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 |
| title_full_unstemmed | EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 |
| title_short | EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 |
| title_sort | evaluation of prostate basal cell by cytokeratin 903 staining in prostatic adenocarcinoma gleason score 6 |
| topic | Gleason score 6 prostate cancer basal cell antikeratin 34β-E12 |
| url | https://juri.urologi.or.id/juri/article/view/341 |
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