Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers
Ultrashort peptides (USPs), consisting of 2–7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/7733 |
| _version_ | 1797406107711307776 |
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| author | Vladimir Khavinson Natalia Linkova Ekaterina Kozhevnikova Anastasiia Dyatlova Mikhael Petukhov |
| author_facet | Vladimir Khavinson Natalia Linkova Ekaterina Kozhevnikova Anastasiia Dyatlova Mikhael Petukhov |
| author_sort | Vladimir Khavinson |
| collection | DOAJ |
| description | Ultrashort peptides (USPs), consisting of 2–7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action. The purpose of this review is to systematize the available data on USP transport involving POT and LAT transporters in various organs and tissues under normal, pathological and ageing conditions. The carriers of the POT family (PEPT1, PEPT2, PHT1, PHT2) transport predominantly di- and tripeptides into the cell. Methods of molecular modeling and physicochemistry have demonstrated the ability of LAT1 to transfer not only amino acids but also some di- and tripeptides into the cell and out of it. LAT1 and 2 are involved in the regulation of the antioxidant, endocrine, immune and nervous systems’ functions. Analysis of the above data allows us to conclude that, depending on their structure, di- and tripeptides can be transported into the cells of various tissues by POT and LAT transporters. This mechanism is likely to underlie the tissue specificity of peptides, their geroprotective action and effectiveness in the case of neuroimmunoendocrine system disorders. |
| first_indexed | 2024-03-09T03:21:33Z |
| format | Article |
| id | doaj.art-7662c3deb2864992a934c370cddd7e9d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:21:33Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7662c3deb2864992a934c370cddd7e9d2023-12-03T15:09:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314773310.3390/ijms23147733Transport of Biologically Active Ultrashort Peptides Using POT and LAT CarriersVladimir Khavinson0Natalia Linkova1Ekaterina Kozhevnikova2Anastasiia Dyatlova3Mikhael Petukhov4Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, RussiaDepartment of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, RussiaDepartment of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, RussiaDepartment of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, RussiaPetersburg Nuclear Physics Institute Named after B.P. Konstantinov, NRC “Kurchatov Institute”, 188300 Gatchina, RussiaUltrashort peptides (USPs), consisting of 2–7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action. The purpose of this review is to systematize the available data on USP transport involving POT and LAT transporters in various organs and tissues under normal, pathological and ageing conditions. The carriers of the POT family (PEPT1, PEPT2, PHT1, PHT2) transport predominantly di- and tripeptides into the cell. Methods of molecular modeling and physicochemistry have demonstrated the ability of LAT1 to transfer not only amino acids but also some di- and tripeptides into the cell and out of it. LAT1 and 2 are involved in the regulation of the antioxidant, endocrine, immune and nervous systems’ functions. Analysis of the above data allows us to conclude that, depending on their structure, di- and tripeptides can be transported into the cells of various tissues by POT and LAT transporters. This mechanism is likely to underlie the tissue specificity of peptides, their geroprotective action and effectiveness in the case of neuroimmunoendocrine system disorders.https://www.mdpi.com/1422-0067/23/14/7733ultrashort peptidesPOTLATpathologypharmacotherapy |
| spellingShingle | Vladimir Khavinson Natalia Linkova Ekaterina Kozhevnikova Anastasiia Dyatlova Mikhael Petukhov Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers International Journal of Molecular Sciences ultrashort peptides POT LAT pathology pharmacotherapy |
| title | Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers |
| title_full | Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers |
| title_fullStr | Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers |
| title_full_unstemmed | Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers |
| title_short | Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers |
| title_sort | transport of biologically active ultrashort peptides using pot and lat carriers |
| topic | ultrashort peptides POT LAT pathology pharmacotherapy |
| url | https://www.mdpi.com/1422-0067/23/14/7733 |
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