Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy Neonates
Background: Respiratory distress syndrome (RDS) is one of the most common causes of mortality in premature neonates and its prevalence is about one percent of all births worldwide. Zinc deficiency causes serious complications, such as low birth weight, intrauterine growth restriction, and disruption...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2017-11-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/8824 |
| _version_ | 1797719093273427968 |
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| author | Behzad Barekatain Masoud Maleki Zohreh Badiee Armindokht Shahsanai Elham Rouhani |
| author_facet | Behzad Barekatain Masoud Maleki Zohreh Badiee Armindokht Shahsanai Elham Rouhani |
| author_sort | Behzad Barekatain |
| collection | DOAJ |
| description | Background: Respiratory distress syndrome (RDS) is one of the most common causes of mortality in premature neonates and its prevalence is about one percent of all births worldwide. Zinc deficiency causes serious complications, such as low birth weight, intrauterine growth restriction, and disruption in many vital organs such as the respiratory system. Therefore, in this study, we aimed to compare the zinc level in umbilical cord blood among premature neonates with RDS and healthy neonates.
Methods: In this case-control study, 40 preterm neonates with RDS were selected as case group and also 40 healthy neonates were selected as control group. After delivery and after cord clamping, a sample of blood from the umbilical artery was collected. All experiments were performed by an operator and by an automatic analyzer.
Findings: The mean zinc level in umbilical cord blood was 96.67 ± 16.45 and 109.07 ± 21.49 mmol/l in the patient and control groups, respectively (P = 0.005). There was a positive and significant association between the zinc level in umbilical cord blood and the age of the neonates (r = 0.23, P = 0.030). Similarly, a significant positive association was found between the weight of the neonates and the zinc level in umbilical cord blood (r = 0.22, P = 0.040).
Conclusion: The zinc level was significantly lower in infants with RDS than healthy neonates. Therefore, the improvement of zinc status in premature neonates may reduce the risk of RDS. |
| first_indexed | 2024-03-12T08:59:45Z |
| format | Article |
| id | doaj.art-76656fe9ae5c4653982598eb41867c8e |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:59:45Z |
| publishDate | 2017-11-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-76656fe9ae5c4653982598eb41867c8e2023-09-02T15:45:34ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2017-11-0111113311382643Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy NeonatesBehzad Barekatain0Masoud Maleki1Zohreh Badiee2Armindokht Shahsanai3Elham Rouhani4Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranClinical and Anatomical Pathologist, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Respiratory distress syndrome (RDS) is one of the most common causes of mortality in premature neonates and its prevalence is about one percent of all births worldwide. Zinc deficiency causes serious complications, such as low birth weight, intrauterine growth restriction, and disruption in many vital organs such as the respiratory system. Therefore, in this study, we aimed to compare the zinc level in umbilical cord blood among premature neonates with RDS and healthy neonates. Methods: In this case-control study, 40 preterm neonates with RDS were selected as case group and also 40 healthy neonates were selected as control group. After delivery and after cord clamping, a sample of blood from the umbilical artery was collected. All experiments were performed by an operator and by an automatic analyzer. Findings: The mean zinc level in umbilical cord blood was 96.67 ± 16.45 and 109.07 ± 21.49 mmol/l in the patient and control groups, respectively (P = 0.005). There was a positive and significant association between the zinc level in umbilical cord blood and the age of the neonates (r = 0.23, P = 0.030). Similarly, a significant positive association was found between the weight of the neonates and the zinc level in umbilical cord blood (r = 0.22, P = 0.040). Conclusion: The zinc level was significantly lower in infants with RDS than healthy neonates. Therefore, the improvement of zinc status in premature neonates may reduce the risk of RDS.http://jims.mui.ac.ir/index.php/jims/article/view/8824NeonatePreterm infantsZincUmbilical cord |
| spellingShingle | Behzad Barekatain Masoud Maleki Zohreh Badiee Armindokht Shahsanai Elham Rouhani Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy Neonates مجله دانشکده پزشکی اصفهان Neonate Preterm infants Zinc Umbilical cord |
| title | Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy Neonates |
| title_full | Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy Neonates |
| title_fullStr | Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy Neonates |
| title_full_unstemmed | Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy Neonates |
| title_short | Comparison of Zinc Level in Umbilical Cord Blood between the Preterm Neonates with Respiratory Distress Syndrome and Healthy Neonates |
| title_sort | comparison of zinc level in umbilical cord blood between the preterm neonates with respiratory distress syndrome and healthy neonates |
| topic | Neonate Preterm infants Zinc Umbilical cord |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/8824 |
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