Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single Center
Background: There are several reports on the prevalence and characteristics of intracranial hemorrhage (ICH) following percutaneous coronary intervention (PCI), which is a rare but severe complication with high mortality. However, the clinical landscapes of computed tomography (CT)-confirmed, sympto...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/14/2422 |
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| author | Cheng Yang Yong-Gang Sui Bin-Cheng Wang Yan-Lu Xu Na-Qiong Wu Yong-Jian Wu Jian-Jun Li Jie Qian |
| author_facet | Cheng Yang Yong-Gang Sui Bin-Cheng Wang Yan-Lu Xu Na-Qiong Wu Yong-Jian Wu Jian-Jun Li Jie Qian |
| author_sort | Cheng Yang |
| collection | DOAJ |
| description | Background: There are several reports on the prevalence and characteristics of intracranial hemorrhage (ICH) following percutaneous coronary intervention (PCI), which is a rare but severe complication with high mortality. However, the clinical landscapes of computed tomography (CT)-confirmed, symptomatic ICH in hospitalized patients are not fully characterized. Methods: Among 121,066 patients receiving PCI treatment in the Fu Wai Hospital between 2013 and 2022, there were 18 CT-defined, symptomatic patients with ICH occurring during post-PCI hospitalization. Symptomatic ICH was defined as clinical suspicion of hemorrhage and/or new focal neurological signs. We analyzed ICH timing, clinical and imaging features, and subsequent outcomes. Results: Overall, in this retrospective analysis, the incidence of CT-defined, symptomatic ICH was 0.015% (18/121,066). More than half of the cases (55.6%) occurred within the first 12 h following PCI. The most common initial manifestation of ICH patients was disturbance of consciousness. Thirteen patients (72.2%) had a hematoma volume ≥ 30 cm<sup>3</sup>. Additionally, the ICH was observed in the cerebral lobe (66.7%), cerebellum (22.2%), and the basal ganglia and thalamus (11.1%). The 90-day mortality of ICH patients undergoing PCI was very high (72.2%). Consciousness disturbance (<i>p</i> = 0.036), intracerebral hemorrhage volume > 30 mm<sup>3</sup> (<i>p</i> = 0.001), and intracerebral hemorrhage originating from the infratentorial origin (<i>p</i> = 0.044) were significantly higher in patients who died. Conclusions: Symptomatic ICH events occur with a rate of around 0.015%, with significantly higher short-term mortality risk in our cohort receiving PCI, which has not yet been demonstrated in other cohorts. |
| first_indexed | 2024-03-11T01:09:45Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T01:09:45Z |
| publishDate | 2023-07-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-766611206c2544d88edac05e17f162142023-11-18T18:58:36ZengMDPI AGDiagnostics2075-44182023-07-011314242210.3390/diagnostics13142422Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single CenterCheng Yang0Yong-Gang Sui1Bin-Cheng Wang2Yan-Lu Xu3Na-Qiong Wu4Yong-Jian Wu5Jian-Jun Li6Jie Qian7Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaBackground: There are several reports on the prevalence and characteristics of intracranial hemorrhage (ICH) following percutaneous coronary intervention (PCI), which is a rare but severe complication with high mortality. However, the clinical landscapes of computed tomography (CT)-confirmed, symptomatic ICH in hospitalized patients are not fully characterized. Methods: Among 121,066 patients receiving PCI treatment in the Fu Wai Hospital between 2013 and 2022, there were 18 CT-defined, symptomatic patients with ICH occurring during post-PCI hospitalization. Symptomatic ICH was defined as clinical suspicion of hemorrhage and/or new focal neurological signs. We analyzed ICH timing, clinical and imaging features, and subsequent outcomes. Results: Overall, in this retrospective analysis, the incidence of CT-defined, symptomatic ICH was 0.015% (18/121,066). More than half of the cases (55.6%) occurred within the first 12 h following PCI. The most common initial manifestation of ICH patients was disturbance of consciousness. Thirteen patients (72.2%) had a hematoma volume ≥ 30 cm<sup>3</sup>. Additionally, the ICH was observed in the cerebral lobe (66.7%), cerebellum (22.2%), and the basal ganglia and thalamus (11.1%). The 90-day mortality of ICH patients undergoing PCI was very high (72.2%). Consciousness disturbance (<i>p</i> = 0.036), intracerebral hemorrhage volume > 30 mm<sup>3</sup> (<i>p</i> = 0.001), and intracerebral hemorrhage originating from the infratentorial origin (<i>p</i> = 0.044) were significantly higher in patients who died. Conclusions: Symptomatic ICH events occur with a rate of around 0.015%, with significantly higher short-term mortality risk in our cohort receiving PCI, which has not yet been demonstrated in other cohorts.https://www.mdpi.com/2075-4418/13/14/2422symptomatic intracranial hemorrhagepercutaneous coronary interventioncoronary artery diseaseincidenceclinical characteristics |
| spellingShingle | Cheng Yang Yong-Gang Sui Bin-Cheng Wang Yan-Lu Xu Na-Qiong Wu Yong-Jian Wu Jian-Jun Li Jie Qian Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single Center Diagnostics symptomatic intracranial hemorrhage percutaneous coronary intervention coronary artery disease incidence clinical characteristics |
| title | Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single Center |
| title_full | Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single Center |
| title_fullStr | Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single Center |
| title_full_unstemmed | Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single Center |
| title_short | Intracranial Hemorrhage in Hospitalized Patients Following Percutaneous Coronary Intervention: A Large Cohort Analysis from a Single Center |
| title_sort | intracranial hemorrhage in hospitalized patients following percutaneous coronary intervention a large cohort analysis from a single center |
| topic | symptomatic intracranial hemorrhage percutaneous coronary intervention coronary artery disease incidence clinical characteristics |
| url | https://www.mdpi.com/2075-4418/13/14/2422 |
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