Protein and mRNA levels support the notion that a genetic regulatory circuit controls growth phases in E. coli populations
Bacterial populations transition between growing and non-growing phases, based on nutrient availability and stresses conditions. The hallmark of a growing state is anabolism, including DNA replication and cell division. In contrast, bacteria in a growth-arrested state acquire a resistant physiology...
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| Format: | Article |
| Language: | English |
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International Academy of Ecology and Environmental Sciences
2015-09-01
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| Series: | Network Biology |
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| Online Access: | http://www.iaees.org/publications/journals/nb/articles/2015-5(3)/a-genetic-regulatory-circuit-controls-growth-phases.pdf |
| Summary: | Bacterial populations transition between growing and non-growing phases, based on nutrient availability and stresses conditions. The hallmark of a growing state is anabolism, including DNA replication and cell division. In contrast, bacteria in a growth-arrested state acquire a resistant physiology and diminished metabolism. However, there is little knowledge on how this transition occurs at the molecular level. Here, we provide new evidence that a multi-element genetic regulatory circuit might work to maintain genetic control among growth-phase transitions in Escherichia coli. This work contributes to the discovering of design principles behind the performance of biological functions, which could be of relevance on the new disciplines of biological engineering and synthetic biology. |
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| ISSN: | 2220-8879 2220-8879 |