High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway
<p>Abstract</p> <p>Background</p> <p>Hyperhomocysteinemia (HHcy) causes increased oxidative stress and is an independent risk factor for cardiovascular disease. Oxidative stress is now believed to be a major contributory factor in the development of non alcoholic fatty...
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| Format: | Article |
| Language: | English |
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BMC
2011-04-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/10/1/60 |
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| author | Napolitano Mariarosaria Cano Ainara Rossi Barbara Buqué Xabier Aspichueta Patricia Palleschi Simonetta Bravo Elena Ochoa Begoña Botham Kathleen M |
| author_facet | Napolitano Mariarosaria Cano Ainara Rossi Barbara Buqué Xabier Aspichueta Patricia Palleschi Simonetta Bravo Elena Ochoa Begoña Botham Kathleen M |
| author_sort | Napolitano Mariarosaria |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Hyperhomocysteinemia (HHcy) causes increased oxidative stress and is an independent risk factor for cardiovascular disease. Oxidative stress is now believed to be a major contributory factor in the development of non alcoholic fatty liver disease, the most common liver disorder worldwide. In this study, the changes which occur in homocysteine (Hcy) metabolism in high fat-diet induced non alcoholic fatty liver disease (NAFLD) in rats were investigated.</p> <p>Methods and results</p> <p>After feeding rats a standard low fat diet (control) or a high fat diet (57% metabolisable energy as fat) for 18 weeks, the concentration of homocysteine in the plasma was significantly raised while that of cysteine was lowered in the high fat as compared to the control diet fed animals. The hepatic activities of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGS), the enzymes responsible for the breakdown of homocysteine to cysteine via the transsulphuration pathway in the liver, were also significantly reduced in the high fat-fed group.</p> <p>Conclusions</p> <p>These results indicate that high fat diet-induced NAFLD in rats is associated with increased plasma Hcy levels caused by down-regulation of hepatic CBS and CGL activity. Thus, HHcy occurs at an early stage in high fat diet-induced NAFLD and is likely to contribute to the increased risk of cardiovascular disease associated with the condition.</p> |
| first_indexed | 2024-04-12T14:26:22Z |
| format | Article |
| id | doaj.art-7669f2104e084999994b587fe18be265 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-12T14:26:22Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-7669f2104e084999994b587fe18be2652022-12-22T03:29:25ZengBMCLipids in Health and Disease1476-511X2011-04-011016010.1186/1476-511X-10-60High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathwayNapolitano MariarosariaCano AinaraRossi BarbaraBuqué XabierAspichueta PatriciaPalleschi SimonettaBravo ElenaOchoa BegoñaBotham Kathleen M<p>Abstract</p> <p>Background</p> <p>Hyperhomocysteinemia (HHcy) causes increased oxidative stress and is an independent risk factor for cardiovascular disease. Oxidative stress is now believed to be a major contributory factor in the development of non alcoholic fatty liver disease, the most common liver disorder worldwide. In this study, the changes which occur in homocysteine (Hcy) metabolism in high fat-diet induced non alcoholic fatty liver disease (NAFLD) in rats were investigated.</p> <p>Methods and results</p> <p>After feeding rats a standard low fat diet (control) or a high fat diet (57% metabolisable energy as fat) for 18 weeks, the concentration of homocysteine in the plasma was significantly raised while that of cysteine was lowered in the high fat as compared to the control diet fed animals. The hepatic activities of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGS), the enzymes responsible for the breakdown of homocysteine to cysteine via the transsulphuration pathway in the liver, were also significantly reduced in the high fat-fed group.</p> <p>Conclusions</p> <p>These results indicate that high fat diet-induced NAFLD in rats is associated with increased plasma Hcy levels caused by down-regulation of hepatic CBS and CGL activity. Thus, HHcy occurs at an early stage in high fat diet-induced NAFLD and is likely to contribute to the increased risk of cardiovascular disease associated with the condition.</p>http://www.lipidworld.com/content/10/1/60Homocysteinehyperhomocysteinemianon alcoholic fatty liver diseasetranssulphuration pathway |
| spellingShingle | Napolitano Mariarosaria Cano Ainara Rossi Barbara Buqué Xabier Aspichueta Patricia Palleschi Simonetta Bravo Elena Ochoa Begoña Botham Kathleen M High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway Lipids in Health and Disease Homocysteine hyperhomocysteinemia non alcoholic fatty liver disease transsulphuration pathway |
| title | High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway |
| title_full | High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway |
| title_fullStr | High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway |
| title_full_unstemmed | High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway |
| title_short | High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway |
| title_sort | high fat diet induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway |
| topic | Homocysteine hyperhomocysteinemia non alcoholic fatty liver disease transsulphuration pathway |
| url | http://www.lipidworld.com/content/10/1/60 |
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