Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease
Periostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and lactate dehydrogenase (LDH) in 19 patients with RA-IL...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/22/7100 |
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| author | Goushi Matama Masaki Okamoto Kiminori Fujimoto Takeshi Johkoh Masaki Tominaga Hiroshi Mukae Noriho Sakamoto Kosaku Komiya Kenji Umeki Masamichi Komatsu Yasuo Shimizu Koichiro Takahashi Saeko Tokisawa Yoshiaki Zaizen Norikazu Matsuo Takashi Nouno Shinjiro Kaieda Hiroaki Ida Kenji Izuhara Tomoaki Hoshino |
| author_facet | Goushi Matama Masaki Okamoto Kiminori Fujimoto Takeshi Johkoh Masaki Tominaga Hiroshi Mukae Noriho Sakamoto Kosaku Komiya Kenji Umeki Masamichi Komatsu Yasuo Shimizu Koichiro Takahashi Saeko Tokisawa Yoshiaki Zaizen Norikazu Matsuo Takashi Nouno Shinjiro Kaieda Hiroaki Ida Kenji Izuhara Tomoaki Hoshino |
| author_sort | Goushi Matama |
| collection | DOAJ |
| description | Periostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and lactate dehydrogenase (LDH) in 19 patients with RA-ILD, 20 RA without ILD, and 137 healthy controls (HC). All biomarkers were higher in RA-ILD than HC or RA without ILD. KL-6 accurately detected ILD in RA patients (area under curve [AUC] = 0.939) and moderately detected SP-D and monomeric and total periostin (AUC = 0.803, =0.767, =0.767, respectively). Monomeric and total periostin were negatively correlated with normal lung area and positively correlated with honeycombing, reticulation, fibrosis score, and the traction bronchiectasis grade but not inflammatory areas. Serum levels of SP-D, KL-6, and LDH did not correlate with the extent of those fibrotic areas on high-resolution CT. Serum monomeric and total periostin were higher in patients with RA-ILD with definite usual interstitial pneumonia pattern compared with other ILD patterns. Immunohistochemical analyses of biopsy or autopsy lung tissues from RA-ILD during the chronic phase and acute exacerbation showed that periostin was expressed in fibroblastic foci but not inflammatory or dense fibrosis lesions. Periostin is a potential biomarker for diagnosis, evaluating fibrosis, and deciding therapeutic strategies for patients with RA-ILD. |
| first_indexed | 2024-03-09T16:43:03Z |
| format | Article |
| id | doaj.art-766b8e9cec294eb6957ea769b823cc37 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:43:03Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-766b8e9cec294eb6957ea769b823cc372023-11-24T14:49:28ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011222710010.3390/jcm12227100Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung DiseaseGoushi Matama0Masaki Okamoto1Kiminori Fujimoto2Takeshi Johkoh3Masaki Tominaga4Hiroshi Mukae5Noriho Sakamoto6Kosaku Komiya7Kenji Umeki8Masamichi Komatsu9Yasuo Shimizu10Koichiro Takahashi11Saeko Tokisawa12Yoshiaki Zaizen13Norikazu Matsuo14Takashi Nouno15Shinjiro Kaieda16Hiroaki Ida17Kenji Izuhara18Tomoaki Hoshino19Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDepartment of Radiology, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDepartment of Radiology, Kansai Rosai Hospital, Inabasou 3-1-69, Amagasaki 660-0064, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8501, JapanDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8501, JapanRespiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Idaigaoka 1-1, Hasama-Machi, Yufu 879-5593, JapanDepartment of Respiratory Medicine, Tenshindo Hetsugi Hospital, Nihongi 5956, Nakahetsugi 879-7761, JapanFirst Department of Internal Medicine, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, JapanDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu 321-0293, JapanDepartment of Respirology, Saga Medical School, Nabeshima 5-1-1, Saga 849-8501, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanDivision of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Nabeshima 5-1-1, Saga 849-8501, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Ashahi-Machi 67, Kurume 830-0011, JapanPeriostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and lactate dehydrogenase (LDH) in 19 patients with RA-ILD, 20 RA without ILD, and 137 healthy controls (HC). All biomarkers were higher in RA-ILD than HC or RA without ILD. KL-6 accurately detected ILD in RA patients (area under curve [AUC] = 0.939) and moderately detected SP-D and monomeric and total periostin (AUC = 0.803, =0.767, =0.767, respectively). Monomeric and total periostin were negatively correlated with normal lung area and positively correlated with honeycombing, reticulation, fibrosis score, and the traction bronchiectasis grade but not inflammatory areas. Serum levels of SP-D, KL-6, and LDH did not correlate with the extent of those fibrotic areas on high-resolution CT. Serum monomeric and total periostin were higher in patients with RA-ILD with definite usual interstitial pneumonia pattern compared with other ILD patterns. Immunohistochemical analyses of biopsy or autopsy lung tissues from RA-ILD during the chronic phase and acute exacerbation showed that periostin was expressed in fibroblastic foci but not inflammatory or dense fibrosis lesions. Periostin is a potential biomarker for diagnosis, evaluating fibrosis, and deciding therapeutic strategies for patients with RA-ILD.https://www.mdpi.com/2077-0383/12/22/7100periostinrheumatoid arthritisinterstitial lung diseasefibrosisbiomarker |
| spellingShingle | Goushi Matama Masaki Okamoto Kiminori Fujimoto Takeshi Johkoh Masaki Tominaga Hiroshi Mukae Noriho Sakamoto Kosaku Komiya Kenji Umeki Masamichi Komatsu Yasuo Shimizu Koichiro Takahashi Saeko Tokisawa Yoshiaki Zaizen Norikazu Matsuo Takashi Nouno Shinjiro Kaieda Hiroaki Ida Kenji Izuhara Tomoaki Hoshino Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease Journal of Clinical Medicine periostin rheumatoid arthritis interstitial lung disease fibrosis biomarker |
| title | Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_full | Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_fullStr | Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_full_unstemmed | Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_short | Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease |
| title_sort | periostin is a biomarker of rheumatoid arthritis associated interstitial lung disease |
| topic | periostin rheumatoid arthritis interstitial lung disease fibrosis biomarker |
| url | https://www.mdpi.com/2077-0383/12/22/7100 |
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