Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area
Oral food challenge (OFC) remains the gold standard for the diagnosis of food allergies. However, this test is not without risks, given that severe allergic reactions can be triggered while it is conducted. The purpose of this study is to identify potential demographic variables, clinical characteri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/10/2463 |
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| author | Teresa Valbuena Marta Reche Guadalupe Marco Inmaculada Toboso Anna Ringauf Israel J. Thuissard-Vasallo Daniel Lozano-Ojalvo Mónica Martínez-Blanco Elena Molina |
| author_facet | Teresa Valbuena Marta Reche Guadalupe Marco Inmaculada Toboso Anna Ringauf Israel J. Thuissard-Vasallo Daniel Lozano-Ojalvo Mónica Martínez-Blanco Elena Molina |
| author_sort | Teresa Valbuena |
| collection | DOAJ |
| description | Oral food challenge (OFC) remains the gold standard for the diagnosis of food allergies. However, this test is not without risks, given that severe allergic reactions can be triggered while it is conducted. The purpose of this study is to identify potential demographic variables, clinical characteristics of the patients and biomarkers that may be associated with severe reactions during the hazelnut oral challenge test. The sample included 22 children allergic to hazelnut who underwent a tree nut skin prick test (SPT), specific IgE (sIgE) to hazelnut, component-resolved diagnosis (CRD) with different hazelnut allergens (Cor a 1, Cor a 8, Cor a 9, Cor a 11, Cor a 14), and a single-blind placebo-controlled challenge with hazelnut. A statistically significant relationship was found between the severity of the reaction and the highest values of sIgE to hazelnut, Cor a 11 and Cor a 14, cumulative symptom-triggering dose and sunflower seed sensitization. The use of the CRD is a useful tool to identify patients at higher risk of developing a severe reaction. In this pediatric population sample from Spain, storage proteins were confirmed to be most involved in hazelnut allergy and the development of severe reactions. |
| first_indexed | 2024-03-10T06:33:46Z |
| format | Article |
| id | doaj.art-766bbd8cc4af4072a5a8092d89afc93c |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T06:33:46Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-766bbd8cc4af4072a5a8092d89afc93c2023-11-22T18:16:32ZengMDPI AGFoods2304-81582021-10-011010246310.3390/foods10102463Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich AreaTeresa Valbuena0Marta Reche1Guadalupe Marco2Inmaculada Toboso3Anna Ringauf4Israel J. Thuissard-Vasallo5Daniel Lozano-Ojalvo6Mónica Martínez-Blanco7Elena Molina8Allergology Department, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, 28702 Madrid, SpainAllergology Department, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, 28702 Madrid, SpainAllergology Department, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, 28702 Madrid, SpainImmunology, Laboratorio Central UR Salud Madrid, San Sebastián de los Reyes, 28702 Madrid, SpainMacro Array Diagnostics, 1230 Wien, AustriaFaculty of Biomedical and Health Science, Universidad Europea de Madrid, 28670 Madrid, SpainIcahn School of Medicine at Mount Sinai, New York, NY 10029, USAInstituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), 28049 Madrid, SpainInstituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), 28049 Madrid, SpainOral food challenge (OFC) remains the gold standard for the diagnosis of food allergies. However, this test is not without risks, given that severe allergic reactions can be triggered while it is conducted. The purpose of this study is to identify potential demographic variables, clinical characteristics of the patients and biomarkers that may be associated with severe reactions during the hazelnut oral challenge test. The sample included 22 children allergic to hazelnut who underwent a tree nut skin prick test (SPT), specific IgE (sIgE) to hazelnut, component-resolved diagnosis (CRD) with different hazelnut allergens (Cor a 1, Cor a 8, Cor a 9, Cor a 11, Cor a 14), and a single-blind placebo-controlled challenge with hazelnut. A statistically significant relationship was found between the severity of the reaction and the highest values of sIgE to hazelnut, Cor a 11 and Cor a 14, cumulative symptom-triggering dose and sunflower seed sensitization. The use of the CRD is a useful tool to identify patients at higher risk of developing a severe reaction. In this pediatric population sample from Spain, storage proteins were confirmed to be most involved in hazelnut allergy and the development of severe reactions.https://www.mdpi.com/2304-8158/10/10/2463hazelnut allergycomponent-resolved diagnosisskin-prick testspecific IgEfood challengeseverity |
| spellingShingle | Teresa Valbuena Marta Reche Guadalupe Marco Inmaculada Toboso Anna Ringauf Israel J. Thuissard-Vasallo Daniel Lozano-Ojalvo Mónica Martínez-Blanco Elena Molina Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area Foods hazelnut allergy component-resolved diagnosis skin-prick test specific IgE food challenge severity |
| title | Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area |
| title_full | Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area |
| title_fullStr | Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area |
| title_full_unstemmed | Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area |
| title_short | Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area |
| title_sort | storage proteins are driving pediatric hazelnut allergy in a lipid transfer protein rich area |
| topic | hazelnut allergy component-resolved diagnosis skin-prick test specific IgE food challenge severity |
| url | https://www.mdpi.com/2304-8158/10/10/2463 |
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