Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H<sub>2</sub>S in DNA repair has been identified, where H<sub>2</sub>S modulates cell cycle checkpoint responses, the DNA dam...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1820 |
| _version_ | 1797511433861201920 |
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| author | Rodney E. Shackelford Yan Li Ghali E. Ghali Christopher G. Kevil |
| author_facet | Rodney E. Shackelford Yan Li Ghali E. Ghali Christopher G. Kevil |
| author_sort | Rodney E. Shackelford |
| collection | DOAJ |
| description | Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H<sub>2</sub>S in DNA repair has been identified, where H<sub>2</sub>S modulates cell cycle checkpoint responses, the DNA damage response (DDR), and mitochondrial and nuclear genomic stability. In addition, several DNA repair proteins modulate cellular H<sub>2</sub>S concentrations and cellular sulfur metabolism and, in turn, are regulated by cellular H<sub>2</sub>S concentrations. Many DDR proteins are now pharmacologically inhibited in targeted cancer therapies. As H<sub>2</sub>S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H<sub>2</sub>S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H<sub>2</sub>S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR–H<sub>2</sub>S signaling axis in these pathophysiologic processes. Taken together, H<sub>2</sub>S and DNA repair likely play a central and presently poorly understood role in both normal cellular function and a wide array of human pathophysiologic processes. Here, we review the role of H<sub>2</sub>S in DNA repair. |
| first_indexed | 2024-03-10T05:45:12Z |
| format | Article |
| id | doaj.art-766bea7475eb41f18ff0e990ece92f1f |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:12Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-766bea7475eb41f18ff0e990ece92f1f2023-11-22T22:14:11ZengMDPI AGAntioxidants2076-39212021-11-011011182010.3390/antiox10111820Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid CooperationRodney E. Shackelford0Yan Li1Ghali E. Ghali2Christopher G. Kevil3Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USADepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USAHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USADepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USAHydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H<sub>2</sub>S in DNA repair has been identified, where H<sub>2</sub>S modulates cell cycle checkpoint responses, the DNA damage response (DDR), and mitochondrial and nuclear genomic stability. In addition, several DNA repair proteins modulate cellular H<sub>2</sub>S concentrations and cellular sulfur metabolism and, in turn, are regulated by cellular H<sub>2</sub>S concentrations. Many DDR proteins are now pharmacologically inhibited in targeted cancer therapies. As H<sub>2</sub>S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H<sub>2</sub>S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H<sub>2</sub>S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR–H<sub>2</sub>S signaling axis in these pathophysiologic processes. Taken together, H<sub>2</sub>S and DNA repair likely play a central and presently poorly understood role in both normal cellular function and a wide array of human pathophysiologic processes. Here, we review the role of H<sub>2</sub>S in DNA repair.https://www.mdpi.com/2076-3921/10/11/1820hydrogen sulfideDNA repaircystathionine β-synthasecystathionine γ-lyase3-mercaptopyruvate sulfurtransferaseATR |
| spellingShingle | Rodney E. Shackelford Yan Li Ghali E. Ghali Christopher G. Kevil Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation Antioxidants hydrogen sulfide DNA repair cystathionine β-synthase cystathionine γ-lyase 3-mercaptopyruvate sulfurtransferase ATR |
| title | Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation |
| title_full | Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation |
| title_fullStr | Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation |
| title_full_unstemmed | Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation |
| title_short | Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation |
| title_sort | bad smells and broken dna a tale of sulfur nucleic acid cooperation |
| topic | hydrogen sulfide DNA repair cystathionine β-synthase cystathionine γ-lyase 3-mercaptopyruvate sulfurtransferase ATR |
| url | https://www.mdpi.com/2076-3921/10/11/1820 |
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