Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with Obesity
Xi Chen,1 Chunlan Zhang,1 Jingping Li,2 Wei Liu,2 Jingjing Zhang,1 Zhiguang Zhou1 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endoc...
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| Format: | Article |
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Dove Medical Press
2020-10-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/effects-of-laparoscopic-sleeve-gastrectomy-on-bone-mineral-density-and-peer-reviewed-article-DMSO |
| _version_ | 1811173935607185408 |
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| author | Chen X Zhang C Li J Liu W Zhang J Zhou Z |
| author_facet | Chen X Zhang C Li J Liu W Zhang J Zhou Z |
| author_sort | Chen X |
| collection | DOAJ |
| description | Xi Chen,1 Chunlan Zhang,1 Jingping Li,2 Wei Liu,2 Jingjing Zhang,1 Zhiguang Zhou1 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of China; 2Department of Metabolic Surgery, Department of Biliopancreatic Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, People’s Republic of ChinaCorrespondence: Jingjing ZhangNational Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of ChinaEmail Doctorzhangjj@csu.edu.cnObjective: Laparoscopic sleeve gastrectomy (LSG) is one of the most effective therapies to treat obesity. Due to a lack of longitudinal research, we explored the changes in BMD and bone metabolism in Chinese patients with obesity before and after LSG.Materials and Methods: A total of 49 obese Chinese patients with obesity were recruited from the Second Xiangya Hospital of Central South University. All patients underwent LSG, and the metabolic indicators were evaluated, including the serum osteocalcin (OC), total-terminal propeptide of type I procollagen (TPINP) and carboxy terminal telopeptide of collagen type I (CTX) levels at baseline and 2, 6 and 12 months postoperatively. Dual energy X-ray absorptiometry (DEXA) was used to measure body composition and BMD before and 12 months after LSG.Results: The body mass index (BMI) significantly decreased at 12 months postoperatively, and no patients developed osteoporosis. The BMD of femoral neck and total hip significantly decreased from the baseline to 12 months postoperatively, while the BMD of lumbar spine did not change significantly. The OC, TPINP and CTX levels significantly increased at 12 months postoperatively. The excess BMI loss (EBMIL) was positively related while the reduction in visceral adipose tissue (VAT) mass was negatively related to the decreases in BMD of the femoral neck and total hip at 12 months postoperatively. The increase in OC was negatively correlated with the decrease in BMD of the femoral neck, while the increase in TPINP was positively correlated with the decrease in BMD of total hip.Conclusion: Based on the 12-month follow-up results, the BMD of the femoral neck and total hip was decreased in Chinese patients with obesity after LSG, while bone remodelling was active. This finding suggested that weight loss, a decrease in the VAT mass and an increase in bone remodelling may be correlated with a reduction in BMD.Keywords: laparoscopic sleeve gastrectomy, obesity, bone mineral density, bone metabolism markers |
| first_indexed | 2024-04-10T17:55:05Z |
| format | Article |
| id | doaj.art-766c66d0ab704634a078b5dd33600f71 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:55:05Z |
| publishDate | 2020-10-01 |
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| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-766c66d0ab704634a078b5dd33600f712023-02-02T18:52:22ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-10-01Volume 134095410358643Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with ObesityChen XZhang CLi JLiu WZhang JZhou ZXi Chen,1 Chunlan Zhang,1 Jingping Li,2 Wei Liu,2 Jingjing Zhang,1 Zhiguang Zhou1 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of China; 2Department of Metabolic Surgery, Department of Biliopancreatic Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, People’s Republic of ChinaCorrespondence: Jingjing ZhangNational Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of ChinaEmail Doctorzhangjj@csu.edu.cnObjective: Laparoscopic sleeve gastrectomy (LSG) is one of the most effective therapies to treat obesity. Due to a lack of longitudinal research, we explored the changes in BMD and bone metabolism in Chinese patients with obesity before and after LSG.Materials and Methods: A total of 49 obese Chinese patients with obesity were recruited from the Second Xiangya Hospital of Central South University. All patients underwent LSG, and the metabolic indicators were evaluated, including the serum osteocalcin (OC), total-terminal propeptide of type I procollagen (TPINP) and carboxy terminal telopeptide of collagen type I (CTX) levels at baseline and 2, 6 and 12 months postoperatively. Dual energy X-ray absorptiometry (DEXA) was used to measure body composition and BMD before and 12 months after LSG.Results: The body mass index (BMI) significantly decreased at 12 months postoperatively, and no patients developed osteoporosis. The BMD of femoral neck and total hip significantly decreased from the baseline to 12 months postoperatively, while the BMD of lumbar spine did not change significantly. The OC, TPINP and CTX levels significantly increased at 12 months postoperatively. The excess BMI loss (EBMIL) was positively related while the reduction in visceral adipose tissue (VAT) mass was negatively related to the decreases in BMD of the femoral neck and total hip at 12 months postoperatively. The increase in OC was negatively correlated with the decrease in BMD of the femoral neck, while the increase in TPINP was positively correlated with the decrease in BMD of total hip.Conclusion: Based on the 12-month follow-up results, the BMD of the femoral neck and total hip was decreased in Chinese patients with obesity after LSG, while bone remodelling was active. This finding suggested that weight loss, a decrease in the VAT mass and an increase in bone remodelling may be correlated with a reduction in BMD.Keywords: laparoscopic sleeve gastrectomy, obesity, bone mineral density, bone metabolism markershttps://www.dovepress.com/effects-of-laparoscopic-sleeve-gastrectomy-on-bone-mineral-density-and-peer-reviewed-article-DMSOlaparoscopic sleeve gastrectomyobesitybone mineral densitybone metabolism markers |
| spellingShingle | Chen X Zhang C Li J Liu W Zhang J Zhou Z Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with Obesity Diabetes, Metabolic Syndrome and Obesity laparoscopic sleeve gastrectomy obesity bone mineral density bone metabolism markers |
| title | Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with Obesity |
| title_full | Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with Obesity |
| title_fullStr | Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with Obesity |
| title_full_unstemmed | Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with Obesity |
| title_short | Effects of Laparoscopic Sleeve Gastrectomy on Bone Mineral Density and Bone Metabolism in Chinese Patients with Obesity |
| title_sort | effects of laparoscopic sleeve gastrectomy on bone mineral density and bone metabolism in chinese patients with obesity |
| topic | laparoscopic sleeve gastrectomy obesity bone mineral density bone metabolism markers |
| url | https://www.dovepress.com/effects-of-laparoscopic-sleeve-gastrectomy-on-bone-mineral-density-and-peer-reviewed-article-DMSO |
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