Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Continence Society
2018-01-01
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| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://www.einj.org/upload/pdf/inj-1835062-531.pdf |
| _version_ | 1818931509104476160 |
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| author | Lori Birder Karl-Erik Andersson |
| author_facet | Lori Birder Karl-Erik Andersson |
| author_sort | Lori Birder |
| collection | DOAJ |
| description | The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment. |
| first_indexed | 2024-12-20T04:17:43Z |
| format | Article |
| id | doaj.art-766d1c03464c49d19264a3c082bb122a |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-20T04:17:43Z |
| publishDate | 2018-01-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-766d1c03464c49d19264a3c082bb122a2022-12-21T19:53:44ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312018-01-0122Suppl 1S3910.5213/inj.1835062.531704Animal Modelling of Interstitial Cystitis/Bladder Pain SyndromeLori Birder0Karl-Erik Andersson1 Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USAThe etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.http://www.einj.org/upload/pdf/inj-1835062-531.pdfInterstitial cystitisBladder pain syndromeAnimal modelsInflammationMucosaStress |
| spellingShingle | Lori Birder Karl-Erik Andersson Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome International Neurourology Journal Interstitial cystitis Bladder pain syndrome Animal models Inflammation Mucosa Stress |
| title | Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome |
| title_full | Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome |
| title_fullStr | Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome |
| title_full_unstemmed | Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome |
| title_short | Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome |
| title_sort | animal modelling of interstitial cystitis bladder pain syndrome |
| topic | Interstitial cystitis Bladder pain syndrome Animal models Inflammation Mucosa Stress |
| url | http://www.einj.org/upload/pdf/inj-1835062-531.pdf |
| work_keys_str_mv | AT loribirder animalmodellingofinterstitialcystitisbladderpainsyndrome AT karlerikandersson animalmodellingofinterstitialcystitisbladderpainsyndrome |