First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonates
Background: Age-specific (24 ± 6 h) predictive value of total serum bilirubin (TSB) ≤6 mg/dl in developing significant hyperbilirubinemia in infants. Materials and Methods: A prospective observational study on 200 term neonates having birth weight ≥2500 g and gestational age ≥37 weeks. Blood was col...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Archives of Medicine and Health Sciences |
| Subjects: | |
| Online Access: | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2018;volume=6;issue=2;spage=218;epage=222;aulast=Allam |
| _version_ | 1818648929154105344 |
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| author | Jehangir Bhat Allam Santosh Kumar Rajesh Kurmi Roshan Ara Amit Mittal Kumar |
| author_facet | Jehangir Bhat Allam Santosh Kumar Rajesh Kurmi Roshan Ara Amit Mittal Kumar |
| author_sort | Jehangir Bhat Allam |
| collection | DOAJ |
| description | Background: Age-specific (24 ± 6 h) predictive value of total serum bilirubin (TSB) ≤6 mg/dl in developing significant hyperbilirubinemia in infants. Materials and Methods: A prospective observational study on 200 term neonates having birth weight ≥2500 g and gestational age ≥37 weeks. Blood was collected from the venous site. The blood sample of all infants was sent for grouping and TSB estimation. Babies were clinically examined every day for jaundice. Whenever jaundice was clinically noticed to be >10 mg/dl, bilirubin estimation was repeated immediately and then every day until 5 days of age, and the highest reading was recorded as the peak TSB. Results: Significant hyperbilirubinemia (>17 mg/dl) was present in 13% of cases. At 24 ± 6 h, TSB >6 mg/dl was present in 47 cases and 26 of these developed hyperbilirubinemia (≥17 mg/dl), and TSB ≤6 mg/dl was present in 153 cases and two of them developed significant hyperbilirubinemia. The incidence of hyperbilirubinemia in babies whose mothers received oxytocin and those whose mothers did not receive oxytocin was 19.6% and 8.2%, respectively. The difference was highly significant. The mean values of TSB at 24 ± 6 h in oxytocin used and oxytocin not used groups were 3.94 ± 2.15 mg/dl and 3.36 ± 1.91 mg/dl, respectively, the difference was statistically significant; however, the mean values of peak TSB in oxytocin used and not used groups were 12.78 ± 4.28 mg/dl and 12.03 ± 3.42 mg/dl, respectively, which were statistically not significant. Conclusion: The incidence of significant hyperbilirubinemia in healthy babies is 13%. The use of oxytocin increased its incidence. TSB at 24 ± 6 h ≤6 mg/dl has a high predictive value in identifying those infants who are unlikely to develop subsequent hyperbilirubinemia. This study, thus, will help to discharge healthy term infants with TSB on 2nd day ≤6 mg/dl. |
| first_indexed | 2024-12-17T01:26:14Z |
| format | Article |
| id | doaj.art-766dc46ea0b04147b60855868788cd1d |
| institution | Directory Open Access Journal |
| issn | 2321-4848 |
| language | English |
| last_indexed | 2024-12-17T01:26:14Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Archives of Medicine and Health Sciences |
| spelling | doaj.art-766dc46ea0b04147b60855868788cd1d2022-12-21T22:08:41ZengWolters Kluwer Medknow PublicationsArchives of Medicine and Health Sciences2321-48482018-01-016221822210.4103/amhs.amhs_42_18First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonatesJehangir Bhat AllamSantosh KumarRajesh KurmiRoshan AraAmit Mittal KumarBackground: Age-specific (24 ± 6 h) predictive value of total serum bilirubin (TSB) ≤6 mg/dl in developing significant hyperbilirubinemia in infants. Materials and Methods: A prospective observational study on 200 term neonates having birth weight ≥2500 g and gestational age ≥37 weeks. Blood was collected from the venous site. The blood sample of all infants was sent for grouping and TSB estimation. Babies were clinically examined every day for jaundice. Whenever jaundice was clinically noticed to be >10 mg/dl, bilirubin estimation was repeated immediately and then every day until 5 days of age, and the highest reading was recorded as the peak TSB. Results: Significant hyperbilirubinemia (>17 mg/dl) was present in 13% of cases. At 24 ± 6 h, TSB >6 mg/dl was present in 47 cases and 26 of these developed hyperbilirubinemia (≥17 mg/dl), and TSB ≤6 mg/dl was present in 153 cases and two of them developed significant hyperbilirubinemia. The incidence of hyperbilirubinemia in babies whose mothers received oxytocin and those whose mothers did not receive oxytocin was 19.6% and 8.2%, respectively. The difference was highly significant. The mean values of TSB at 24 ± 6 h in oxytocin used and oxytocin not used groups were 3.94 ± 2.15 mg/dl and 3.36 ± 1.91 mg/dl, respectively, the difference was statistically significant; however, the mean values of peak TSB in oxytocin used and not used groups were 12.78 ± 4.28 mg/dl and 12.03 ± 3.42 mg/dl, respectively, which were statistically not significant. Conclusion: The incidence of significant hyperbilirubinemia in healthy babies is 13%. The use of oxytocin increased its incidence. TSB at 24 ± 6 h ≤6 mg/dl has a high predictive value in identifying those infants who are unlikely to develop subsequent hyperbilirubinemia. This study, thus, will help to discharge healthy term infants with TSB on 2nd day ≤6 mg/dl.http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2018;volume=6;issue=2;spage=218;epage=222;aulast=AllamFirst-day serum bilirubin levelneonatal hyperbilirubinemiaoxytocin-induced hyperbilirubinemiasignificant hyperbilirubinemia |
| spellingShingle | Jehangir Bhat Allam Santosh Kumar Rajesh Kurmi Roshan Ara Amit Mittal Kumar First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonates Archives of Medicine and Health Sciences First-day serum bilirubin level neonatal hyperbilirubinemia oxytocin-induced hyperbilirubinemia significant hyperbilirubinemia |
| title | First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonates |
| title_full | First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonates |
| title_fullStr | First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonates |
| title_full_unstemmed | First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonates |
| title_short | First day serum bilirubin level, as predictor of significant hyperbilirubinemia in neonates |
| title_sort | first day serum bilirubin level as predictor of significant hyperbilirubinemia in neonates |
| topic | First-day serum bilirubin level neonatal hyperbilirubinemia oxytocin-induced hyperbilirubinemia significant hyperbilirubinemia |
| url | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2018;volume=6;issue=2;spage=218;epage=222;aulast=Allam |
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