Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure
Congestive heart failure (CHF) is a multifaceted cardiovascular condition that imposes significant economic and social burdens on society, while also presenting a dearth of efficacious treatment modalities. Long non-coding RNAs (lncRNAs) possess the ability to influence the pathophysiological mechan...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-03-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S246805402300080X |
| _version_ | 1797267184571908096 |
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| author | Changjin Li Mingyao Zhou Xiaowei Song Songqun Huang Zhifu Guo |
| author_facet | Changjin Li Mingyao Zhou Xiaowei Song Songqun Huang Zhifu Guo |
| author_sort | Changjin Li |
| collection | DOAJ |
| description | Congestive heart failure (CHF) is a multifaceted cardiovascular condition that imposes significant economic and social burdens on society, while also presenting a dearth of efficacious treatment modalities. Long non-coding RNAs (lncRNAs) possess the ability to influence the pathophysiological mechanisms underlying cardiac disease through their regulation of gene transcription, translation, and post-translational modifications. Additionally, certain lncRNAs can be encoded by the mitochondrial genome, hence impacting mitochondrial function. The heart relies heavily on mitochondrial oxidative phosphorylation for approximately 95 % of its ATP production. Consequently, the primary determinant linking mitochondrial dysfunction to heart failure is the impairment of cardiac energy supply resulting from mitochondrial injury. Cardiac dysfunction can arise as a result of various factors, including metabolic disease, disturbances in calcium homeostasis, oxidative stress, apoptosis, and mitochondrial phagocytosis, all of which are facilitated by mitochondrial damage. Currently, an increasing body of research indicates that lncRNA plays a significant role in the regulation of mitochondrial activity, hence impacting heart failure. As a result, the goal of this paper is to propose new ideas and targets for clinical research and therapy of heart failure by reviewing recent research on the regulatory mechanism of mitochondrial function by novel lncRNAs. |
| first_indexed | 2024-03-09T14:46:31Z |
| format | Article |
| id | doaj.art-766e39bf2e1e46508cb164f06e6b3472 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-25T01:12:33Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Non-coding RNA Research |
| spelling | doaj.art-766e39bf2e1e46508cb164f06e6b34722024-03-10T05:12:29ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-03-0191178184Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failureChangjin Li0Mingyao Zhou1Xiaowei Song2Songqun Huang3Zhifu Guo4Department of Cardiology, Changhai Hospital, Naval Medical University, No. 168, Changhai Road, Yangpu District, Shanghai, 200433, ChinaDepartment of Cardiology, Changhai Hospital, Naval Medical University, No. 168, Changhai Road, Yangpu District, Shanghai, 200433, ChinaDepartment of Cardiology, Changhai Hospital, Naval Medical University, No. 168, Changhai Road, Yangpu District, Shanghai, 200433, ChinaCorresponding author.; Department of Cardiology, Changhai Hospital, Naval Medical University, No. 168, Changhai Road, Yangpu District, Shanghai, 200433, ChinaCorresponding author.; Department of Cardiology, Changhai Hospital, Naval Medical University, No. 168, Changhai Road, Yangpu District, Shanghai, 200433, ChinaCongestive heart failure (CHF) is a multifaceted cardiovascular condition that imposes significant economic and social burdens on society, while also presenting a dearth of efficacious treatment modalities. Long non-coding RNAs (lncRNAs) possess the ability to influence the pathophysiological mechanisms underlying cardiac disease through their regulation of gene transcription, translation, and post-translational modifications. Additionally, certain lncRNAs can be encoded by the mitochondrial genome, hence impacting mitochondrial function. The heart relies heavily on mitochondrial oxidative phosphorylation for approximately 95 % of its ATP production. Consequently, the primary determinant linking mitochondrial dysfunction to heart failure is the impairment of cardiac energy supply resulting from mitochondrial injury. Cardiac dysfunction can arise as a result of various factors, including metabolic disease, disturbances in calcium homeostasis, oxidative stress, apoptosis, and mitochondrial phagocytosis, all of which are facilitated by mitochondrial damage. Currently, an increasing body of research indicates that lncRNA plays a significant role in the regulation of mitochondrial activity, hence impacting heart failure. As a result, the goal of this paper is to propose new ideas and targets for clinical research and therapy of heart failure by reviewing recent research on the regulatory mechanism of mitochondrial function by novel lncRNAs.http://www.sciencedirect.com/science/article/pii/S246805402300080XLong non-coding RNAMitochondriaCongestive heart failure |
| spellingShingle | Changjin Li Mingyao Zhou Xiaowei Song Songqun Huang Zhifu Guo Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure Non-coding RNA Research Long non-coding RNA Mitochondria Congestive heart failure |
| title | Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure |
| title_full | Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure |
| title_fullStr | Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure |
| title_full_unstemmed | Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure |
| title_short | Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure |
| title_sort | regulatory mechanisms of long non coding rnas on mitochondrial function in congestive heart failure |
| topic | Long non-coding RNA Mitochondria Congestive heart failure |
| url | http://www.sciencedirect.com/science/article/pii/S246805402300080X |
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