Advances of target therapy on NOTCH1 signaling pathway in T-cell acute lymphoblastic leukemia

Advances of target therapy on NOTCH1 signaling pathway in T-cell acute lymphoblastic leukemia

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is one of the hematological malignancies. With the applications of chemotherapy regimens and allogeneic hematopoietic stem cell transplantation, the cure rate of T-ALL has been significantly improved. However, patients with relapsed and refractory...

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Bibliographic Details
Main Authors: Ruyue Zheng, Menglin Li, Shujuan Wang, Yanfang Liu
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Experimental Hematology & Oncology
Subjects:
T-cell acute lymphoblastic leukemia
NOTCH1
γ-Secretase inhibitors
SERCA inhibitors
Monoclonal antibody
Online Access:http://link.springer.com/article/10.1186/s40164-020-00187-x

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