A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

Abstract Background Little is known about parameters that have a relevant impact on (dis)similarities in biodistribution between various 68Ga-labeled somatostatin analogues. Additionally, the effect of tumor burden on organ uptake remains unclear. Therefore, the aim of this study was to describe and...

Full description

Bibliographic Details
Main Authors: Hinke Siebinga, Berlinda J. de Wit-van der Veen, Jos H. Beijnen, Thomas P. C. Dorlo, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx
Format: Article
Language:English
Published: SpringerOpen 2023-02-01
Series:EJNMMI Research
Subjects:
PBPK
68Ga-DOTATATE
68Ga-HA-DOTATATE
Whole-body distribution
Tumor sink effect
Online Access:https://doi.org/10.1186/s13550-023-00958-7

Similar Items

Similar Items