Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
Abstract Objective Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), cons...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-022-06008-0 |
| _version_ | 1818066790906855424 |
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| author | Hanna Lee Young Sun Suh Sang-Il Lee Yun-Hong Cheon Mingyo Kim Hae Sook Noh Hyun-Ok Kim |
| author_facet | Hanna Lee Young Sun Suh Sang-Il Lee Yun-Hong Cheon Mingyo Kim Hae Sook Noh Hyun-Ok Kim |
| author_sort | Hanna Lee |
| collection | DOAJ |
| description | Abstract Objective Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent with our previous study. Therefore, the present study aimed to reproduce the previous results. Results The serum IGFBP-3 level was not significantly different among the three groups according to disease activity based on the DAS28-ESR/CRP (p > 0.05) but was significantly different between the low- and high-disease-activity groups based on the DAS28-CRP (p = 0.036). Meanwhile, the interleukin-6 (IL-6) level moderately correlated with DAS28-CRP (Spearman’s rho = 0.583, p < 0.001). |
| first_indexed | 2024-12-10T15:13:23Z |
| format | Article |
| id | doaj.art-76718687902b432499df5ac6ad419f1e |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-10T15:13:23Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-76718687902b432499df5ac6ad419f1e2022-12-22T01:43:52ZengBMCBMC Research Notes1756-05002022-04-011511510.1186/s13104-022-06008-0Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activityHanna Lee0Young Sun Suh1Sang-Il Lee2Yun-Hong Cheon3Mingyo Kim4Hae Sook Noh5Hyun-Ok Kim6Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine and HospitalDivision of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Changwon HospitalDivision of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine and HospitalDivision of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine and HospitalDivision of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine and HospitalDivision of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Institute of Health Science, Gyeongsang National University HospitalDivision of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Changwon HospitalAbstract Objective Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent with our previous study. Therefore, the present study aimed to reproduce the previous results. Results The serum IGFBP-3 level was not significantly different among the three groups according to disease activity based on the DAS28-ESR/CRP (p > 0.05) but was significantly different between the low- and high-disease-activity groups based on the DAS28-CRP (p = 0.036). Meanwhile, the interleukin-6 (IL-6) level moderately correlated with DAS28-CRP (Spearman’s rho = 0.583, p < 0.001).https://doi.org/10.1186/s13104-022-06008-0Rheumatoid arthritisDisease activityInsulin-like growth factor-1Insulin-like growth factor binding protein-3 |
| spellingShingle | Hanna Lee Young Sun Suh Sang-Il Lee Yun-Hong Cheon Mingyo Kim Hae Sook Noh Hyun-Ok Kim Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity BMC Research Notes Rheumatoid arthritis Disease activity Insulin-like growth factor-1 Insulin-like growth factor binding protein-3 |
| title | Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity |
| title_full | Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity |
| title_fullStr | Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity |
| title_full_unstemmed | Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity |
| title_short | Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity |
| title_sort | serum igf 1 in patients with rheumatoid arthritis correlation with disease activity |
| topic | Rheumatoid arthritis Disease activity Insulin-like growth factor-1 Insulin-like growth factor binding protein-3 |
| url | https://doi.org/10.1186/s13104-022-06008-0 |
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