Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drug
In this work a novel pH sensitive composite, polyacrylamide grafted succinyl chitosan intercalated bentonite (AAm-g-NB/SC) was prepared as a drug carrier system for the controlled delivery of paclitaxel. Characterization of the drug delivery system was carried out using Fourier transform infrared sp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535220300733 |
| _version_ | 1818316108810158080 |
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| author | R. Surya Manohar D. Mullassery Noeline B. Fernandez Diana Thomas Prasad S. Jayaram |
| author_facet | R. Surya Manohar D. Mullassery Noeline B. Fernandez Diana Thomas Prasad S. Jayaram |
| author_sort | R. Surya |
| collection | DOAJ |
| description | In this work a novel pH sensitive composite, polyacrylamide grafted succinyl chitosan intercalated bentonite (AAm-g-NB/SC) was prepared as a drug carrier system for the controlled delivery of paclitaxel. Characterization of the drug delivery system was carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal analysis etc. The equilibrium swelling behaviour of the composite was studied and the result showed a maximum at pH 7.4. The in vitro drug release study of paclitaxel indicated that about 15.6% of drug release was found to be occurred at pH 1.2 within 16 h, whereas about 82.5% of drug release was occurred at the intestinal pH condition of 7.4. In vitro biocompatibility study was performed and the result showed good biocompatibility of the composite in the concentration range 6.25–100 µg/mL. The cytotoxicity assay was carried out in cancerous cell line of Human colorectal Adenocarcinoma. Mucous glycoprotein assay study showed that the drug delivery system having good apparent adhering property towards mucin. The investigation indicated that paclitaxel, an anticancer drug can be successfully entrapped in the AAm-g-NB/SC composite for the controlled and targeted delivery for colorectal cancer therapy. |
| first_indexed | 2024-12-13T09:16:12Z |
| format | Article |
| id | doaj.art-7672c25d26bc43c49f102c1c5b4c2e50 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-13T09:16:12Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-7672c25d26bc43c49f102c1c5b4c2e502022-12-21T23:52:50ZengElsevierArabian Journal of Chemistry1878-53522020-05-0113552625276Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drugR. Surya0Manohar D. Mullassery1Noeline B. Fernandez2Diana Thomas3Prasad S. Jayaram4Department of Chemistry, Fatima Mata National College, Kollam 691001, IndiaDepartment of Chemistry, Fatima Mata National College, Kollam 691001, India; Corresponding author.Department of Chemistry, Fatima Mata National College, Kollam 691001, IndiaDepartment of Chemistry, Fatima Mata National College, Kollam 691001, IndiaNational Centre for Biological Sciences, Bangalore, IndiaIn this work a novel pH sensitive composite, polyacrylamide grafted succinyl chitosan intercalated bentonite (AAm-g-NB/SC) was prepared as a drug carrier system for the controlled delivery of paclitaxel. Characterization of the drug delivery system was carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal analysis etc. The equilibrium swelling behaviour of the composite was studied and the result showed a maximum at pH 7.4. The in vitro drug release study of paclitaxel indicated that about 15.6% of drug release was found to be occurred at pH 1.2 within 16 h, whereas about 82.5% of drug release was occurred at the intestinal pH condition of 7.4. In vitro biocompatibility study was performed and the result showed good biocompatibility of the composite in the concentration range 6.25–100 µg/mL. The cytotoxicity assay was carried out in cancerous cell line of Human colorectal Adenocarcinoma. Mucous glycoprotein assay study showed that the drug delivery system having good apparent adhering property towards mucin. The investigation indicated that paclitaxel, an anticancer drug can be successfully entrapped in the AAm-g-NB/SC composite for the controlled and targeted delivery for colorectal cancer therapy.http://www.sciencedirect.com/science/article/pii/S1878535220300733ChitosanBentonitePaclitaxelControlled drug deliveryMucin |
| spellingShingle | R. Surya Manohar D. Mullassery Noeline B. Fernandez Diana Thomas Prasad S. Jayaram Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drug Arabian Journal of Chemistry Chitosan Bentonite Paclitaxel Controlled drug delivery Mucin |
| title | Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drug |
| title_full | Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drug |
| title_fullStr | Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drug |
| title_full_unstemmed | Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drug |
| title_short | Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the controlled release application of anti-cancerous drug |
| title_sort | synthesis and characterization of a ph responsive and mucoadhesive drug delivery system for the controlled release application of anti cancerous drug |
| topic | Chitosan Bentonite Paclitaxel Controlled drug delivery Mucin |
| url | http://www.sciencedirect.com/science/article/pii/S1878535220300733 |
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