Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus
Various important transcription factors in the pancreas are involved in the process of pancreas development, the differentiation of endocrine progenitor cells into mature insulin-producing pancreatic β-cells and the preservation of mature β-cell function. However, when β-cells are continuously expos...
Main Authors: | Hideaki Kaneto, Tomohiko Kimura, Masashi Shimoda, Atsushi Obata, Junpei Sanada, Yoshiro Fushimi, Taka-aki Matsuoka, Kohei Kaku |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-03-01
|
Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/10/4/818 |
Similar Items
-
Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine
by: Hideaki Kaneto, et al.
Published: (2021-07-01) -
Notable Underlying Mechanism for Pancreatic β-Cell Dysfunction and Atherosclerosis: Pleiotropic Roles of Incretin and Insulin Signaling
by: Hideaki Kaneto, et al.
Published: (2020-12-01) -
Exploring Large MAF Transcription Factors: Functions, Pathology, and Mouse Models with Point Mutations
by: Mitsunori Fujino, et al.
Published: (2023-09-01) -
Specific reprogramming of alpha cells to insulin-producing cells by short glucagon promoter-driven Pdx1 and MafA
by: Ping Guo, et al.
Published: (2023-03-01) -
p43, a Truncated Form of Thyroid Hormone Receptor α, Regulates Maturation of Pancreatic β Cells
by: Emilie Blanchet, et al.
Published: (2021-03-01)