Traditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh
This study was aimed at evaluating the antioxidant and antidiabetic activities of methanolic extracts of peel, flesh and mixed peel, and flesh, as well as the cytotoxic activity of mixed peel and flesh extracts obtained from fruits of six traditional pear varieties (Vidovača, Lubeničarka, Karamanka,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade
2021-10-01
|
| Series: | Botanica Serbica |
| Subjects: | |
| Online Access: | https://botanicaserbica.bio.bg.ac.rs/arhiva/pdf/2021_45_2_801_full.pdf |
| _version_ | 1818730973547724800 |
|---|---|
| author | Mariana Oalđe Pavlović Ana Alimpić Aradski Aleksandra Savić Smiljana Janković Milena Milutinović Petar D. Marin Sonja Duletić-Laušević |
| author_facet | Mariana Oalđe Pavlović Ana Alimpić Aradski Aleksandra Savić Smiljana Janković Milena Milutinović Petar D. Marin Sonja Duletić-Laušević |
| author_sort | Mariana Oalđe Pavlović |
| collection | DOAJ |
| description | This study was aimed at evaluating the antioxidant and antidiabetic activities of methanolic extracts of peel, flesh and mixed peel, and flesh, as well as the cytotoxic activity of mixed peel and flesh extracts obtained from fruits of six traditional pear varieties (Vidovača, Lubeničarka, Karamanka, Jeribasma, Lončara and Takiša), one commercial variety (Williams Bartlett) and a wild pear (Pyrus communis) from Serbia. The tested extracts showed strong antioxidant activity regarding the prevention of β-carotene bleaching and high α-glucosidase inhibition, and no significant cytotoxic potential, with the exception of the Williams Bartlett and Pyrus communis extracts. Overall, the most potent fruit part was shown to be the peel. The most active variety in all of the applied antioxidant and antidiabetic assays was Takiša, while the wild pear, P. communis, was the most effective in inhibiting the proliferation of cancer cells. In conclusion, several methanolic extracts of pear fruit are promising candidates for further studies regarding the prevention and treatment of pathological conditions associated with the effects of oxidative stress, such as diabetes and even colorectal cancer |
| first_indexed | 2024-12-17T23:10:17Z |
| format | Article |
| id | doaj.art-76744bb68b9b4092a6d284b0c67fc7f2 |
| institution | Directory Open Access Journal |
| issn | 1821-2158 1821-2638 |
| language | English |
| last_indexed | 2024-12-17T23:10:17Z |
| publishDate | 2021-10-01 |
| publisher | University of Belgrade |
| record_format | Article |
| series | Botanica Serbica |
| spelling | doaj.art-76744bb68b9b4092a6d284b0c67fc7f22022-12-21T21:29:09ZengUniversity of BelgradeBotanica Serbica1821-21581821-26382021-10-0145220321310.2298/BOTSERB2102203OTraditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and fleshMariana Oalđe Pavlović0Ana Alimpić Aradski1Aleksandra Savić2Smiljana Janković3Milena Milutinović4Petar D. Marin5Sonja Duletić-Laušević6University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden Jevremovac, Studentski trg 16, 11000 Belgrade, SerbiaUniversity of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden Jevremovac, Studentski trg 16, 11000 Belgrade, SerbiaNatural History Museum Belgrade, Njegoševa 51, 11000 Belgrade, SerbiaUniversity of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden Jevremovac, Studentski trg 16, 11000 Belgrade, SerbiaUniversity of Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovića 12, 34000 Kragujevac, SerbiaUniversity of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden Jevremovac, Studentski trg 16, 11000 Belgrade, SerbiaUniversity of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden Jevremovac, Studentski trg 16, 11000 Belgrade, SerbiaThis study was aimed at evaluating the antioxidant and antidiabetic activities of methanolic extracts of peel, flesh and mixed peel, and flesh, as well as the cytotoxic activity of mixed peel and flesh extracts obtained from fruits of six traditional pear varieties (Vidovača, Lubeničarka, Karamanka, Jeribasma, Lončara and Takiša), one commercial variety (Williams Bartlett) and a wild pear (Pyrus communis) from Serbia. The tested extracts showed strong antioxidant activity regarding the prevention of β-carotene bleaching and high α-glucosidase inhibition, and no significant cytotoxic potential, with the exception of the Williams Bartlett and Pyrus communis extracts. Overall, the most potent fruit part was shown to be the peel. The most active variety in all of the applied antioxidant and antidiabetic assays was Takiša, while the wild pear, P. communis, was the most effective in inhibiting the proliferation of cancer cells. In conclusion, several methanolic extracts of pear fruit are promising candidates for further studies regarding the prevention and treatment of pathological conditions associated with the effects of oxidative stress, such as diabetes and even colorectal cancerhttps://botanicaserbica.bio.bg.ac.rs/arhiva/pdf/2021_45_2_801_full.pdfpearextractsantioxidant activityantidiabetic activitycytotoxic activity |
| spellingShingle | Mariana Oalđe Pavlović Ana Alimpić Aradski Aleksandra Savić Smiljana Janković Milena Milutinović Petar D. Marin Sonja Duletić-Laušević Traditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh Botanica Serbica pear extracts antioxidant activity antidiabetic activity cytotoxic activity |
| title | Traditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh |
| title_full | Traditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh |
| title_fullStr | Traditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh |
| title_full_unstemmed | Traditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh |
| title_short | Traditional varieties and wild pear from Serbia: a link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh |
| title_sort | traditional varieties and wild pear from serbia a link among antioxidant antidiabetic and cytotoxic activities of fruit peel and flesh |
| topic | pear extracts antioxidant activity antidiabetic activity cytotoxic activity |
| url | https://botanicaserbica.bio.bg.ac.rs/arhiva/pdf/2021_45_2_801_full.pdf |
| work_keys_str_mv | AT marianaoalđepavlovic traditionalvarietiesandwildpearfromserbiaalinkamongantioxidantantidiabeticandcytotoxicactivitiesoffruitpeelandflesh AT anaalimpicaradski traditionalvarietiesandwildpearfromserbiaalinkamongantioxidantantidiabeticandcytotoxicactivitiesoffruitpeelandflesh AT aleksandrasavic traditionalvarietiesandwildpearfromserbiaalinkamongantioxidantantidiabeticandcytotoxicactivitiesoffruitpeelandflesh AT smiljanajankovic traditionalvarietiesandwildpearfromserbiaalinkamongantioxidantantidiabeticandcytotoxicactivitiesoffruitpeelandflesh AT milenamilutinovic traditionalvarietiesandwildpearfromserbiaalinkamongantioxidantantidiabeticandcytotoxicactivitiesoffruitpeelandflesh AT petardmarin traditionalvarietiesandwildpearfromserbiaalinkamongantioxidantantidiabeticandcytotoxicactivitiesoffruitpeelandflesh AT sonjaduleticlausevic traditionalvarietiesandwildpearfromserbiaalinkamongantioxidantantidiabeticandcytotoxicactivitiesoffruitpeelandflesh |