Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach
Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/10/5486 |
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| author | Caio Bezerra Machado Leidivan Sousa da Cunha Jersey Heitor da Silva Maués Flávia Melo Cunha de Pinho Pessoa Marcelo Braga de Oliveira Rodrigo Monteiro Ribeiro Germison Silva Lopes Manoel Odorico de Moraes Filho Maria Elisabete Amaral de Moraes André Salim Khayat Caroline Aquino Moreira-Nunes |
| author_facet | Caio Bezerra Machado Leidivan Sousa da Cunha Jersey Heitor da Silva Maués Flávia Melo Cunha de Pinho Pessoa Marcelo Braga de Oliveira Rodrigo Monteiro Ribeiro Germison Silva Lopes Manoel Odorico de Moraes Filho Maria Elisabete Amaral de Moraes André Salim Khayat Caroline Aquino Moreira-Nunes |
| author_sort | Caio Bezerra Machado |
| collection | DOAJ |
| description | Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. Therefore, we sought to analyze studies that reported deregulated miRNA expression in HTLV-1 infected cells and patients’ samples to understand how this deregulation could induce malignancy. Through in silico analysis, we identified 12 miRNAs that stood out in the prediction of targets, and we performed functional annotation of the genes linked to these 12 miRNAs that appeared to have a major biological interaction. A total of 90 genes were enriched in 14 KEGG pathways with significant values, including TP53, WNT, MAPK, TGF-β, and Ras signaling pathways. These miRNAs and gene interactions are discussed in further detail for elucidation of how they may act as probable drivers for ATL onset, and while our data provide solid starting points for comprehension of miRNAs’ roles in HTLV-1 infection, continuous effort in oncologic research is still needed to improve our understanding of HTLV-1 induced leukemia. |
| first_indexed | 2024-03-10T03:44:29Z |
| format | Article |
| id | doaj.art-767604f08b7d4483ae41ee334be3d823 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:44:29Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-767604f08b7d4483ae41ee334be3d8232023-11-23T11:23:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012310548610.3390/ijms23105486Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics ApproachCaio Bezerra Machado0Leidivan Sousa da Cunha1Jersey Heitor da Silva Maués2Flávia Melo Cunha de Pinho Pessoa3Marcelo Braga de Oliveira4Rodrigo Monteiro Ribeiro5Germison Silva Lopes6Manoel Odorico de Moraes Filho7Maria Elisabete Amaral de Moraes8André Salim Khayat9Caroline Aquino Moreira-Nunes10Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilUnichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, BrazilHematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-970, SP, BrazilDepartment of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilDepartment of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, BrazilDepartment of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, CE, BrazilDepartment of Hematology, César Cals General Hospital, Fortaleza 60015-152, CE, BrazilDepartment of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilDepartment of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilDepartment of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, BrazilDepartment of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilHuman T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. Therefore, we sought to analyze studies that reported deregulated miRNA expression in HTLV-1 infected cells and patients’ samples to understand how this deregulation could induce malignancy. Through in silico analysis, we identified 12 miRNAs that stood out in the prediction of targets, and we performed functional annotation of the genes linked to these 12 miRNAs that appeared to have a major biological interaction. A total of 90 genes were enriched in 14 KEGG pathways with significant values, including TP53, WNT, MAPK, TGF-β, and Ras signaling pathways. These miRNAs and gene interactions are discussed in further detail for elucidation of how they may act as probable drivers for ATL onset, and while our data provide solid starting points for comprehension of miRNAs’ roles in HTLV-1 infection, continuous effort in oncologic research is still needed to improve our understanding of HTLV-1 induced leukemia.https://www.mdpi.com/1422-0067/23/10/5486HTLV-1T cell leukemiamiRNAscarcinogenesis |
| spellingShingle | Caio Bezerra Machado Leidivan Sousa da Cunha Jersey Heitor da Silva Maués Flávia Melo Cunha de Pinho Pessoa Marcelo Braga de Oliveira Rodrigo Monteiro Ribeiro Germison Silva Lopes Manoel Odorico de Moraes Filho Maria Elisabete Amaral de Moraes André Salim Khayat Caroline Aquino Moreira-Nunes Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach International Journal of Molecular Sciences HTLV-1 T cell leukemia miRNAs carcinogenesis |
| title | Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach |
| title_full | Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach |
| title_fullStr | Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach |
| title_full_unstemmed | Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach |
| title_short | Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach |
| title_sort | role of mirnas in human t cell leukemia virus type 1 induced t cell leukemia a literature review and bioinformatics approach |
| topic | HTLV-1 T cell leukemia miRNAs carcinogenesis |
| url | https://www.mdpi.com/1422-0067/23/10/5486 |
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