Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's disease
Traditional Chinese medicine (TCM) has the characteristics of multi-component, multi-target, and biological systems coordination, which meet the criteria of the network pharmacological application. Therefore, using network pharmacology to discover the relationship between TCM, diseases, and cellular...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=2;spage=120;epage=130;aulast=Tsai |
| _version_ | 1797775358040211456 |
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| author | Sheng-Tzung Tsai Hsin-Yi Huang |
| author_facet | Sheng-Tzung Tsai Hsin-Yi Huang |
| author_sort | Sheng-Tzung Tsai |
| collection | DOAJ |
| description | Traditional Chinese medicine (TCM) has the characteristics of multi-component, multi-target, and biological systems coordination, which meet the criteria of the network pharmacological application. Therefore, using network pharmacology to discover the relationship between TCM, diseases, and cellular responses is easily achievable. Aging-induced imbalanced homeostasis is a risk factor for Alzheimer's disease (AD), a neuronal disease regulated by multiple genes. Meta-analysis of TCM in metabolic regulation to improve symptoms of AD helps understand the pharmacological effects. The drug targets of TCM can be investigated using a holistic network pharmacology approach to find potential modulators involved in AD-related metabolic pathways. Based on the theoretical prediction of TCM for AD, experimental validation is needed to develop pure compounds for specific treatments. |
| first_indexed | 2024-03-12T22:34:32Z |
| format | Article |
| id | doaj.art-76770f10251d4ab7b455b64a58e73cdf |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-03-12T22:34:32Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-76770f10251d4ab7b455b64a58e73cdf2023-07-21T13:08:21ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562023-01-0135212013010.4103/tcmj.tcmj_125_22Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's diseaseSheng-Tzung TsaiHsin-Yi HuangTraditional Chinese medicine (TCM) has the characteristics of multi-component, multi-target, and biological systems coordination, which meet the criteria of the network pharmacological application. Therefore, using network pharmacology to discover the relationship between TCM, diseases, and cellular responses is easily achievable. Aging-induced imbalanced homeostasis is a risk factor for Alzheimer's disease (AD), a neuronal disease regulated by multiple genes. Meta-analysis of TCM in metabolic regulation to improve symptoms of AD helps understand the pharmacological effects. The drug targets of TCM can be investigated using a holistic network pharmacology approach to find potential modulators involved in AD-related metabolic pathways. Based on the theoretical prediction of TCM for AD, experimental validation is needed to develop pure compounds for specific treatments.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=2;spage=120;epage=130;aulast=Tsaialzheimer's diseasenetwork pharmacologytraditional chinese medicine |
| spellingShingle | Sheng-Tzung Tsai Hsin-Yi Huang Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's disease Tzu-Chi Medical Journal alzheimer's disease network pharmacology traditional chinese medicine |
| title | Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's disease |
| title_full | Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's disease |
| title_fullStr | Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's disease |
| title_full_unstemmed | Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's disease |
| title_short | Network pharmacology implicates traditional Chinese medicine in regulating systemic homeostasis to benefit Alzheimer's disease |
| title_sort | network pharmacology implicates traditional chinese medicine in regulating systemic homeostasis to benefit alzheimer s disease |
| topic | alzheimer's disease network pharmacology traditional chinese medicine |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=2;spage=120;epage=130;aulast=Tsai |
| work_keys_str_mv | AT shengtzungtsai networkpharmacologyimplicatestraditionalchinesemedicineinregulatingsystemichomeostasistobenefitalzheimersdisease AT hsinyihuang networkpharmacologyimplicatestraditionalchinesemedicineinregulatingsystemichomeostasistobenefitalzheimersdisease |