Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications
Abstract Bone tissue engineering is becoming an ideal strategy to replace autologous bone grafts for surgical bone repair, but the multihierarchical complexity of natural bone is still difficult to emulate due to the lack of suitable biomaterials. Supramolecular peptide nanofiber hydrogels (SPNHs) a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202103820 |
| _version_ | 1811335190749904896 |
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| author | Zhuowen Hao Hanke Li Yi Wang Yingkun Hu Tianhong Chen Shuwei Zhang Xiaodong Guo Lin Cai Jingfeng Li |
| author_facet | Zhuowen Hao Hanke Li Yi Wang Yingkun Hu Tianhong Chen Shuwei Zhang Xiaodong Guo Lin Cai Jingfeng Li |
| author_sort | Zhuowen Hao |
| collection | DOAJ |
| description | Abstract Bone tissue engineering is becoming an ideal strategy to replace autologous bone grafts for surgical bone repair, but the multihierarchical complexity of natural bone is still difficult to emulate due to the lack of suitable biomaterials. Supramolecular peptide nanofiber hydrogels (SPNHs) are emerging biomaterials because of their inherent biocompatibility, satisfied biodegradability, high purity, facile functionalization, and tunable mechanical properties. This review initially focuses on the multihierarchical fabrications by SPNHs to emulate natural bony extracellular matrix. Structurally, supramolecular peptides based on distinctive building blocks can assemble into nanofiber hydrogels, which can be used as nanomorphology‐mimetic scaffolds for tissue engineering. Biochemically, bioactive motifs and bioactive factors can be covalently tethered or physically absorbed to SPNHs to endow various functions depending on physiological and pharmacological requirements. Mechanically, four strategies are summarized to optimize the biophysical microenvironment of SPNHs for bone regeneration. Furthermore, comprehensive applications about SPNHs for bone tissue engineering are reviewed. The biomaterials can be directly used in the form of injectable hydrogels or composite nanoscaffolds, or they can be used to construct engineered bone grafts by bioprinting or bioreactors. Finally, continuing challenges and outlook are discussed. |
| first_indexed | 2024-04-13T17:20:30Z |
| format | Article |
| id | doaj.art-7678a72a23da41e8a31051b78b88e5a3 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-13T17:20:30Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-7678a72a23da41e8a31051b78b88e5a32022-12-22T02:38:00ZengWileyAdvanced Science2198-38442022-04-01911n/an/a10.1002/advs.202103820Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive ApplicationsZhuowen Hao0Hanke Li1Yi Wang2Yingkun Hu3Tianhong Chen4Shuwei Zhang5Xiaodong Guo6Lin Cai7Jingfeng Li8Department of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaDepartment of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaDepartment of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaDepartment of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaDepartment of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaDepartment of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaDepartment of Orthopedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Jiefang Road 1277 Wuhan 430022 ChinaDepartment of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaDepartment of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 Wuhan 430071 ChinaAbstract Bone tissue engineering is becoming an ideal strategy to replace autologous bone grafts for surgical bone repair, but the multihierarchical complexity of natural bone is still difficult to emulate due to the lack of suitable biomaterials. Supramolecular peptide nanofiber hydrogels (SPNHs) are emerging biomaterials because of their inherent biocompatibility, satisfied biodegradability, high purity, facile functionalization, and tunable mechanical properties. This review initially focuses on the multihierarchical fabrications by SPNHs to emulate natural bony extracellular matrix. Structurally, supramolecular peptides based on distinctive building blocks can assemble into nanofiber hydrogels, which can be used as nanomorphology‐mimetic scaffolds for tissue engineering. Biochemically, bioactive motifs and bioactive factors can be covalently tethered or physically absorbed to SPNHs to endow various functions depending on physiological and pharmacological requirements. Mechanically, four strategies are summarized to optimize the biophysical microenvironment of SPNHs for bone regeneration. Furthermore, comprehensive applications about SPNHs for bone tissue engineering are reviewed. The biomaterials can be directly used in the form of injectable hydrogels or composite nanoscaffolds, or they can be used to construct engineered bone grafts by bioprinting or bioreactors. Finally, continuing challenges and outlook are discussed.https://doi.org/10.1002/advs.202103820applicationsbone regenerationfabricationsnanofiber hydrogelssupramolecular peptides |
| spellingShingle | Zhuowen Hao Hanke Li Yi Wang Yingkun Hu Tianhong Chen Shuwei Zhang Xiaodong Guo Lin Cai Jingfeng Li Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications Advanced Science applications bone regeneration fabrications nanofiber hydrogels supramolecular peptides |
| title | Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications |
| title_full | Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications |
| title_fullStr | Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications |
| title_full_unstemmed | Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications |
| title_short | Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications |
| title_sort | supramolecular peptide nanofiber hydrogels for bone tissue engineering from multihierarchical fabrications to comprehensive applications |
| topic | applications bone regeneration fabrications nanofiber hydrogels supramolecular peptides |
| url | https://doi.org/10.1002/advs.202103820 |
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