Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients
Objectives: To compare the prevalence of unexplained pulmonary artery hypertension (PAH) in hemodialysis (HD) and peritoneal dialysis (PD) patients and to compare laboratory parameters between patients with unexplained PAH and those with normal pulmonary artery pressure (PAP). Methods: We retrospect...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-01-01
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| Series: | Revista Portuguesa de Pneumologia |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0873215911001000 |
| _version_ | 1819106506285514752 |
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| author | J. Etemadi H. Zolfaghari R. Firoozi M.R. Ardalan M. Toufan M.M. Shoja K. Ghabili |
| author_facet | J. Etemadi H. Zolfaghari R. Firoozi M.R. Ardalan M. Toufan M.M. Shoja K. Ghabili |
| author_sort | J. Etemadi |
| collection | DOAJ |
| description | Objectives: To compare the prevalence of unexplained pulmonary artery hypertension (PAH) in hemodialysis (HD) and peritoneal dialysis (PD) patients and to compare laboratory parameters between patients with unexplained PAH and those with normal pulmonary artery pressure (PAP). Methods: We retrospectively reviewed the medical records of 278 chronic HD and 145 chronic PD patients. Laboratory findings including hemoglobin, calcium, phosphorus, alkaline phosphatase, albumin, parathyroid hormone level, serum iron, total iron binding capacity, ferritin, creatinine and blood urea nitrogen were documented. The results of transthoracic Doppler echocardiography were used to determine the pulmonary artery pressure (PAP). PAH was defined as a systolic pulmonary artery pressure (SPAP) â¥35 mmHg. To rule out secondary PAH, patients with cardiac disease, pulmonary disease, collagen vascular disease, volume overload at the time of echocardiography and positive human immunodeficiency virus test were excluded. Results: Data from 34 patients in group HD and 32 individuals in group PD were analyzed. The median age of the study population was 57 (45â68) years. The median SPAP value in patients with PAH was 37.5 (35â45) mmHg. According to the echocardiographic findings, PAH was found in 14 (41.1%) patients of HD group and in 6 (18.7%) patients of PD group (P = 0.04). The median serum iron and hemoglobin was significantly lower in patients with PAH compared to those in patients with normal PAP (P < 0.05). Conclusion: Unexplained PAH seems to be more frequent in patients undergoing HD than patients in PD group. Moreover, hemoglobin and serum iron levels are lower in patients with PAH compared to those in normal PAP group. Resumo: Objetivos: Comparar a prevalência de hipertensão arterial pulmonar (PAH) inexplicável em doentes sob hemodiálise (HD) e diálise peritoneal (PD) e comparar os parâmetros laboratoriais entre doentes com PAH inexplicável e aqueles com pressão arterial pulmonar normal (PAP). Métodos: Revimos, de forma retrospetiva, os registos médicos de 278 doentes com HD crónica e 145 com PD crónica. Dos dados laboratoriais foram registadas hemoglobina, cálcio, fósforo, fosfatase alcalina, albumina, nÃvel de paratormona, ferro sérico, capacidade total de ligação de ferro, ferritina, creatinina e nitrogénio ureico no sangue. Os resultados do ecocardiograma doppler transtorácico foram utilizados para determinar a pressão arterial pulmonar (PAP). A PAH foi definida como uma pressão arterial pulmonar sistólica (SPAP) â¥35 mmHg. Para excluir a PAH secundária, foram excluÃdos os pacientes com problemas cardÃacos, doenças pulmonares, doenças vasculares do colagénio, excesso de volume na altura do ecocardiograma e vÃrus de imunodeficiência humana positivo. Resultados: Foram analisados dados de 34 pacientes no HD e 32 indivÃduos no grupo PD. A mediana de idade da população estudada foi de 57 (45â68) anos. O valor médio de SPAP em doentes com PAH foi de 37,5 (35â45) mmHg. De acordo com os resultados do ecocardiograma, a PAH foi registada em 14 (41,1%) pacientes do grupo HD e em 6 (18,7%) pacientes do grupo PD (P = 0,04). A mediana do ferro sérico médio e da hemoglobina estavam significativamente mais baixos em pacientes com PAH em comparação com os pacientes com PAP normal (P < 0,05). Conclusão: A PAH inexplicável parece ser mais frequente em pacientes com HD do que em pacientes no grupo de PD. Além disso, os nÃveis de hemoglobina e ferro sérico são inferiores em pacientes com PAH comparando com os do grupo de PAP normal. Keywords: Unexplained pulmonary hypertension, Peritoneal dialysis, Hemodialysis, Palavras-chave: Hipertensão arterial pulmonar inexplicável, Diálise peritoneal, Hemodiálise |
| first_indexed | 2024-12-22T02:39:13Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 0873-2159 |
| language | English |
| last_indexed | 2024-12-22T02:39:13Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Portuguesa de Pneumologia |
| spelling | doaj.art-767af33fdfbb4bc884488ee55f1bd2cf2022-12-21T18:41:41ZengElsevierRevista Portuguesa de Pneumologia0873-21592012-01-011811014Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patientsJ. Etemadi0H. Zolfaghari1R. Firoozi2M.R. Ardalan3M. Toufan4M.M. Shoja5K. Ghabili6Department of Nephrology, Dialysis and Transplantation, Tabriz University of Medical Sciences, Tabriz, IranFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Cardiology, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Nephrology, Dialysis and Transplantation, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Cardiology, Tabriz University of Medical Sciences, Tabriz, IranMedical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author.Objectives: To compare the prevalence of unexplained pulmonary artery hypertension (PAH) in hemodialysis (HD) and peritoneal dialysis (PD) patients and to compare laboratory parameters between patients with unexplained PAH and those with normal pulmonary artery pressure (PAP). Methods: We retrospectively reviewed the medical records of 278 chronic HD and 145 chronic PD patients. Laboratory findings including hemoglobin, calcium, phosphorus, alkaline phosphatase, albumin, parathyroid hormone level, serum iron, total iron binding capacity, ferritin, creatinine and blood urea nitrogen were documented. The results of transthoracic Doppler echocardiography were used to determine the pulmonary artery pressure (PAP). PAH was defined as a systolic pulmonary artery pressure (SPAP) â¥35 mmHg. To rule out secondary PAH, patients with cardiac disease, pulmonary disease, collagen vascular disease, volume overload at the time of echocardiography and positive human immunodeficiency virus test were excluded. Results: Data from 34 patients in group HD and 32 individuals in group PD were analyzed. The median age of the study population was 57 (45â68) years. The median SPAP value in patients with PAH was 37.5 (35â45) mmHg. According to the echocardiographic findings, PAH was found in 14 (41.1%) patients of HD group and in 6 (18.7%) patients of PD group (P = 0.04). The median serum iron and hemoglobin was significantly lower in patients with PAH compared to those in patients with normal PAP (P < 0.05). Conclusion: Unexplained PAH seems to be more frequent in patients undergoing HD than patients in PD group. Moreover, hemoglobin and serum iron levels are lower in patients with PAH compared to those in normal PAP group. Resumo: Objetivos: Comparar a prevalência de hipertensão arterial pulmonar (PAH) inexplicável em doentes sob hemodiálise (HD) e diálise peritoneal (PD) e comparar os parâmetros laboratoriais entre doentes com PAH inexplicável e aqueles com pressão arterial pulmonar normal (PAP). Métodos: Revimos, de forma retrospetiva, os registos médicos de 278 doentes com HD crónica e 145 com PD crónica. Dos dados laboratoriais foram registadas hemoglobina, cálcio, fósforo, fosfatase alcalina, albumina, nÃvel de paratormona, ferro sérico, capacidade total de ligação de ferro, ferritina, creatinina e nitrogénio ureico no sangue. Os resultados do ecocardiograma doppler transtorácico foram utilizados para determinar a pressão arterial pulmonar (PAP). A PAH foi definida como uma pressão arterial pulmonar sistólica (SPAP) â¥35 mmHg. Para excluir a PAH secundária, foram excluÃdos os pacientes com problemas cardÃacos, doenças pulmonares, doenças vasculares do colagénio, excesso de volume na altura do ecocardiograma e vÃrus de imunodeficiência humana positivo. Resultados: Foram analisados dados de 34 pacientes no HD e 32 indivÃduos no grupo PD. A mediana de idade da população estudada foi de 57 (45â68) anos. O valor médio de SPAP em doentes com PAH foi de 37,5 (35â45) mmHg. De acordo com os resultados do ecocardiograma, a PAH foi registada em 14 (41,1%) pacientes do grupo HD e em 6 (18,7%) pacientes do grupo PD (P = 0,04). A mediana do ferro sérico médio e da hemoglobina estavam significativamente mais baixos em pacientes com PAH em comparação com os pacientes com PAP normal (P < 0,05). Conclusão: A PAH inexplicável parece ser mais frequente em pacientes com HD do que em pacientes no grupo de PD. Além disso, os nÃveis de hemoglobina e ferro sérico são inferiores em pacientes com PAH comparando com os do grupo de PAP normal. Keywords: Unexplained pulmonary hypertension, Peritoneal dialysis, Hemodialysis, Palavras-chave: Hipertensão arterial pulmonar inexplicável, Diálise peritoneal, Hemodiálisehttp://www.sciencedirect.com/science/article/pii/S0873215911001000 |
| spellingShingle | J. Etemadi H. Zolfaghari R. Firoozi M.R. Ardalan M. Toufan M.M. Shoja K. Ghabili Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients Revista Portuguesa de Pneumologia |
| title | Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients |
| title_full | Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients |
| title_fullStr | Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients |
| title_full_unstemmed | Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients |
| title_short | Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients |
| title_sort | unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients |
| url | http://www.sciencedirect.com/science/article/pii/S0873215911001000 |
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