Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials
Abstract Time‐restricted eating (TRE) is a new therapeutic strategy for the management of weight loss and dysmetabolic diseases. At present, TRE (8/16, 8 h eating:16 h fasting) is the most common form of TRE. Therefore, this meta‐analysis included randomized controlled trials (RCTs) on TRE (8/16) in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Food Science & Nutrition |
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| Online Access: | https://doi.org/10.1002/fsn3.3194 |
| _version_ | 1811154909237608448 |
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| author | Lu Huang Yan Chen Shu Wen Danhua Lu Xiaoyang Shen Hongxia Deng Liangzhi Xu |
| author_facet | Lu Huang Yan Chen Shu Wen Danhua Lu Xiaoyang Shen Hongxia Deng Liangzhi Xu |
| author_sort | Lu Huang |
| collection | DOAJ |
| description | Abstract Time‐restricted eating (TRE) is a new therapeutic strategy for the management of weight loss and dysmetabolic diseases. At present, TRE (8/16, 8 h eating:16 h fasting) is the most common form of TRE. Therefore, this meta‐analysis included randomized controlled trials (RCTs) on TRE (8/16) in overweight and obese adults to determine its impact on body weight and metabolism. Articles reviewed from PubMed, Ovid MEDLINE, Embase, and Cochrane Central Register for the relevant RCTs that compared TRE (8/16) to non‐TRE in overweight and obese adults. Eight RCTs were included in this meta‐analysis. Participants following TRE (8/16) showed significant body weight reduction (mean difference [MD]: −1.48 kg, 95% confidence interval [CI]: −2.53 to −0.44) and fat mass reduction (MD: −1.09 kg, 95% CI: −1.55 to −0.63). There was no significant difference in lean mass change with TRE intervention (MD: −0.48 kg, 95% CI: −1.02 to 0.05, p = .08, I2 = 41%). The energy restriction and early TRE (eTRE) subgroups resulted in greater weight loss. TRE (8/16) showed beneficial effects on the homeostatic model assessment of insulin resistance (HOMA‐IR, MD: −0.32, 95% CI: −0.59 to −0.06), but had no significant effect on other parameters of glucose metabolism and lipid profiles. In conclusion, TRE (8/16), especially eTRE, or in combination with caloric intake restriction, is a potential therapeutic strategy for weight control in overweight and obese adults. TRE (8/16) also reduced HOMA‐IR; therefore, it may have a positive effect on glucose metabolism. |
| first_indexed | 2024-04-10T04:25:06Z |
| format | Article |
| id | doaj.art-767c4f2176ec4fa4a562aef7f3493191 |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-04-10T04:25:06Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-767c4f2176ec4fa4a562aef7f34931912023-03-10T17:16:13ZengWileyFood Science & Nutrition2048-71772023-03-011131187120010.1002/fsn3.3194Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trialsLu Huang0Yan Chen1Shu Wen2Danhua Lu3Xiaoyang Shen4Hongxia Deng5Liangzhi Xu6Department of Obstetrics and Gynecology, West China Second University Hospital Sichuan University Chengdu ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital Sichuan University Chengdu ChinaDepartment of Critical Care Medicine West China Hospital of Sichuan University Chengdu ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital Sichuan University Chengdu ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital Sichuan University Chengdu ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital Sichuan University Chengdu ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital Sichuan University Chengdu ChinaAbstract Time‐restricted eating (TRE) is a new therapeutic strategy for the management of weight loss and dysmetabolic diseases. At present, TRE (8/16, 8 h eating:16 h fasting) is the most common form of TRE. Therefore, this meta‐analysis included randomized controlled trials (RCTs) on TRE (8/16) in overweight and obese adults to determine its impact on body weight and metabolism. Articles reviewed from PubMed, Ovid MEDLINE, Embase, and Cochrane Central Register for the relevant RCTs that compared TRE (8/16) to non‐TRE in overweight and obese adults. Eight RCTs were included in this meta‐analysis. Participants following TRE (8/16) showed significant body weight reduction (mean difference [MD]: −1.48 kg, 95% confidence interval [CI]: −2.53 to −0.44) and fat mass reduction (MD: −1.09 kg, 95% CI: −1.55 to −0.63). There was no significant difference in lean mass change with TRE intervention (MD: −0.48 kg, 95% CI: −1.02 to 0.05, p = .08, I2 = 41%). The energy restriction and early TRE (eTRE) subgroups resulted in greater weight loss. TRE (8/16) showed beneficial effects on the homeostatic model assessment of insulin resistance (HOMA‐IR, MD: −0.32, 95% CI: −0.59 to −0.06), but had no significant effect on other parameters of glucose metabolism and lipid profiles. In conclusion, TRE (8/16), especially eTRE, or in combination with caloric intake restriction, is a potential therapeutic strategy for weight control in overweight and obese adults. TRE (8/16) also reduced HOMA‐IR; therefore, it may have a positive effect on glucose metabolism.https://doi.org/10.1002/fsn3.3194body weightmeta‐analysismetabolismsystematic reviewtime‐restricted eating |
| spellingShingle | Lu Huang Yan Chen Shu Wen Danhua Lu Xiaoyang Shen Hongxia Deng Liangzhi Xu Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials Food Science & Nutrition body weight meta‐analysis metabolism systematic review time‐restricted eating |
| title | Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials |
| title_full | Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials |
| title_fullStr | Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials |
| title_full_unstemmed | Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials |
| title_short | Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials |
| title_sort | is time restricted eating 8 16 beneficial for body weight and metabolism of obese and overweight adults a systematic review and meta analysis of randomized controlled trials |
| topic | body weight meta‐analysis metabolism systematic review time‐restricted eating |
| url | https://doi.org/10.1002/fsn3.3194 |
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