Correlation analysis of BMP-6 and age-related neovascular macular degeneration
AIM: To investigate the correlations between aqueous concentrations of bone morphogenetic protein 6(BMP-6), interleukin 6(IL-6), and vascular endothelial growth factor(VEGF)and the parameters of macular edema acquired by optical coherence tomography(OCT)in patients with neovascular age-related macul...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-11-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2018/11/201811036.pdf |
| _version_ | 1818765636379082752 |
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| author | Li Chen Yang Hao Zhi-Chao Zhang Ming Liu |
| author_facet | Li Chen Yang Hao Zhi-Chao Zhang Ming Liu |
| author_sort | Li Chen |
| collection | DOAJ |
| description | AIM: To investigate the correlations between aqueous concentrations of bone morphogenetic protein 6(BMP-6), interleukin 6(IL-6), and vascular endothelial growth factor(VEGF)and the parameters of macular edema acquired by optical coherence tomography(OCT)in patients with neovascular age-related macular degeneration(nARMD). <p>METHODS: Totally 35 eyes from 34 patients with nARMD were studied. Twenty eyes from 20 patients with no retinal pathology who underwent cataract surgery served as controls. The central subfield macular thickness(CSMT)of nARMD within 1 mm was measured with OCT. Aqueous humor samples were collected just before intravitreal ranibizumab injection in 35 eyes with nARMD and before cataract surgery in 20 control eyes. Concentration of BMP-6 were determined by ELISA. IL-6, VEGF were measured by cytometric bead array(CBA). <p>RESULTS: The level of BMP-6 in aqueous humor of patients with nARMD(35.29±4.27pg/mL)was significantly lower than that of control eyes(62.04±2.78pg/mL, <i>P</i><0.05), while VEGF level was 93.13±47.25pg/mL, significantly higher than that of the control group 69.21±13.40pg/mL(<i>P</i><0.05). The level of IL-6 was not significantly different between the two groups. BMP-6 was negatively correlated with CSMT(<i>r</i>=-0.409, <i>P</i>=0.015). <p>CONCLUSION: Aqueous humor concentrations of BMP-6 are decreased in eyes with nARMD. Aqueous humor concentrations of VEGF are elevated in eyes with nARMD. BMP-6 could be associated with the pathogenesis of nARMD. |
| first_indexed | 2024-12-18T08:21:14Z |
| format | Article |
| id | doaj.art-767d4d65abdc4aa195e8f99b53e07056 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-18T08:21:14Z |
| publishDate | 2018-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-767d4d65abdc4aa195e8f99b53e070562022-12-21T21:14:44ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232018-11-0118112092209510.3980/j.issn.1672-5123.2018.11.36Correlation analysis of BMP-6 and age-related neovascular macular degenerationLi Chen0Yang Hao1Zhi-Chao Zhang2Ming Liu3Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaInstitute of Neurobiology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an No.1 Hospital, Xi'an 710061, Shaanxi Province, ChinaAIM: To investigate the correlations between aqueous concentrations of bone morphogenetic protein 6(BMP-6), interleukin 6(IL-6), and vascular endothelial growth factor(VEGF)and the parameters of macular edema acquired by optical coherence tomography(OCT)in patients with neovascular age-related macular degeneration(nARMD). <p>METHODS: Totally 35 eyes from 34 patients with nARMD were studied. Twenty eyes from 20 patients with no retinal pathology who underwent cataract surgery served as controls. The central subfield macular thickness(CSMT)of nARMD within 1 mm was measured with OCT. Aqueous humor samples were collected just before intravitreal ranibizumab injection in 35 eyes with nARMD and before cataract surgery in 20 control eyes. Concentration of BMP-6 were determined by ELISA. IL-6, VEGF were measured by cytometric bead array(CBA). <p>RESULTS: The level of BMP-6 in aqueous humor of patients with nARMD(35.29±4.27pg/mL)was significantly lower than that of control eyes(62.04±2.78pg/mL, <i>P</i><0.05), while VEGF level was 93.13±47.25pg/mL, significantly higher than that of the control group 69.21±13.40pg/mL(<i>P</i><0.05). The level of IL-6 was not significantly different between the two groups. BMP-6 was negatively correlated with CSMT(<i>r</i>=-0.409, <i>P</i>=0.015). <p>CONCLUSION: Aqueous humor concentrations of BMP-6 are decreased in eyes with nARMD. Aqueous humor concentrations of VEGF are elevated in eyes with nARMD. BMP-6 could be associated with the pathogenesis of nARMD.http://ies.ijo.cn/cn_publish/2018/11/201811036.pdfbone morphogenetic protein 6neovascular age-related macular degenerationinterleukin 6vascular endothelial growth factorcentral subfield macular thickness |
| spellingShingle | Li Chen Yang Hao Zhi-Chao Zhang Ming Liu Correlation analysis of BMP-6 and age-related neovascular macular degeneration Guoji Yanke Zazhi bone morphogenetic protein 6 neovascular age-related macular degeneration interleukin 6 vascular endothelial growth factor central subfield macular thickness |
| title | Correlation analysis of BMP-6 and age-related neovascular macular degeneration |
| title_full | Correlation analysis of BMP-6 and age-related neovascular macular degeneration |
| title_fullStr | Correlation analysis of BMP-6 and age-related neovascular macular degeneration |
| title_full_unstemmed | Correlation analysis of BMP-6 and age-related neovascular macular degeneration |
| title_short | Correlation analysis of BMP-6 and age-related neovascular macular degeneration |
| title_sort | correlation analysis of bmp 6 and age related neovascular macular degeneration |
| topic | bone morphogenetic protein 6 neovascular age-related macular degeneration interleukin 6 vascular endothelial growth factor central subfield macular thickness |
| url | http://ies.ijo.cn/cn_publish/2018/11/201811036.pdf |
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